02 August 2020: Database Analysis
Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment
Mengyu Sun 1ACE , Jieping Qiu 1BCF , Huazheng Zhai 1BDF , Yaoqun Wang 1DF , Panpan Ma 1EF , Mengying Li 1E , Bo Chen 2AG*DOI: 10.12659/MSM.924604
Med Sci Monit 2020; 26:e924604
Table 1 Univariate and multivariate Cox regression analysis of the training set, testing set, and overall patients group.
| Covariates | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Training set (=174) | ||||
| Age (ref. ≤65) | 1.640 (1.005–2.677) | 0.048 | 1.758 (1.062–2.908) | 0.028 |
| Gender (ref. Female) | 1.660 (0.970–2.841) | 0.065 | 1.335 (0.773–2.303) | 0.300 |
| ISUP grade (ref. 1–2) | 1.283 (0.777–2.116) | 0.330 | 1.459 (0.869–2.451) | 0.153 |
| Stage_T (ref. T1–T2) | 2.637 (1.332–5.221) | 0.005 | 2.287 (1.078–4.849) | 0.031 |
| Stage_N (ref. N0) | 1.825 (1.031–3.231) | 0.039 | 0.640 (0.252–1.623) | 0.347 |
| Stage_M (ref. M0) | 0.218 (0.087–0.550) | 0.001 | 1.975 (0.747–5.221) | 0.170 |
| AJCC stage (ref. I–II) | 2.306 (1.379–3.855) | 0.001 | 1.802 (0.762–4.266) | 0.180 |
| Risk model (ref. low) | 4.669 (2.715–8.029) | 0.000 | 4.634 (2.611–8.224) | 0.000 |
| Testing test (=174) | ||||
| Age (ref. ≤65) | 1.319 (0.828–2.101) | 0.243 | 1.727 (1.031–2.892) | 0.038 |
| Gender (ref. Female) | 1.089 (0.662–1.793) | 0.736 | 1.277 (0.767–2.128) | 0.347 |
| ISUP grade (ref. 1–2) | 1.610 (0.988–2.625) | 0.056 | 1.619 (0.955–2.743) | 0.074 |
| Stage_T (ref. T1–T2) | 1.432 (0.808–2.535) | 0.218 | 1.027 (0.520–2.031) | 0.938 |
| Stage_N (ref. N0) | 2.245 (1.206–4.179) | 0.011 | 1.924 (0.874–4.236) | 0.104 |
| Stage_M (ref. M0) | 1.087 (0.435–2.714) | 0.858 | 1.329 (0.487–3.628) | 0.579 |
| AJCC stage (ref. I–II) | 1.754 (1.067–2.885) | 0.027 | 1.226 (0.599–2.506) | 0.577 |
| Risk model (ref. low) | 1.680 (1.044–2.703) | 0.032 | 1.666 (1.022–2.714) | 0.041 |
| Overall (=348) | ||||
| Age (ref. ≤65) | 1.460 (1.044–2.041) | 0.027 | 1.824 (1.279–2.603) | 0.001 |
| Gender (ref. Female) | 1.348 (0.938–1.939) | 0.107 | 1.382 (0.957–1.995) | 0.084 |
| ISUP grade (ref. 1–2) | 1.433 (1.011–2.033) | 0.043 | 1.480 (1.033–2.120) | 0.033 |
| Stage_T (ref. T1–T2) | 1.901 (1.229–2.940) | 0.004 | 1.468 (0.896–2.404) | 0.127 |
| Stage_N (ref. N0) | 2.005 (1.318–3.049) | 0.001 | 1.212 (0.679–2.166) | 0.515 |
| Stage_M (ref. M0) | 1.818 (0.954–3.465) | 0.069 | 1.662 (0.839–3.294) | 0.145 |
| AJCC stage (ref. I–II) | 2.009 (1.408–2.868) | 0.000 | 1.438 (0.845–2.448) | 0.180 |
| Risk model (ref. low) | 2.733 (1.924–3.883) | 0.000 | 2.608 (1.826–3.726) | 0.000 |
| HR – hazard ration; CI – confidence interval AJCC – American Joint Committee on Cancer. | ||||