09 August 2020 : Clinical Research
Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1α (HIF-1α) Expression
Xiaoxu Fang1B, Dandan Zhang2CD, Wei Zhao3CD, Longfei Gao4DE, Lanping Wang5ABCDEF*DOI: 10.12659/MSM.924670
Med Sci Monit 2020; 26:e924670
Table 4 Relationship between DAAM2 and clinical factors.
| Factors | DAAM2 | P* | |
|---|---|---|---|
| Low | High | ||
| Sex | |||
| Female | 14 | 23 | 0.047 |
| Male | 46 | 34 | |
| Age | |||
| <50 | 25 | 21 | 0.705 |
| ≥50 | 35 | 36 | |
| Tumor size (cm) | |||
| ≤5 | 28 | 17 | 0.087 |
| >5 | 32 | 40 | |
| Tumor number | |||
| Single | 55 | 52 | 0.932 |
| Multiple | 5 | 5 | |
| Histopathological grade | |||
| I+II | 44 | 40 | 0.837 |
| III | 16 | 17 | |
| HBsAg | |||
| Negative | 19 | 17 | 0.844 |
| Positive | 41 | 40 | |
| HCV | |||
| Negative | 57 | 50 | 0.197 |
| Positive | 3 | 7 | |
| Microvascular invasion | |||
| Negative | 24 | 30 | 0.392 |
| Positive | 33 | 30 | |
| Cirrhosis | |||
| Negative | 35 | 28 | 0.357 |
| Positive | 25 | 29 | |
| T stage | |||
| I+II | 35 | 22 | 0.032 |
| III+IV | 25 | 35 | |
| N stage | |||
| N0 | 59 | 56 | 0.971 |
| N1 | 1 | 1 | |
| TNM stage | |||
| I+II | 35 | 22 | 0.032 |
| III+IV | 25 | 35 | |
| DAAM1 | |||
| Low | 48 | 47 | 0.815 |
| High | 12 | 10 | |
| * Calculated by the Chi-square test. HBsAg – hepatitis B surface antien; HCV – hepatitis C virus. | |||