18 October 2020 : Clinical Research
Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease
Yongxiang Zhang1ABCDE, Yuechuan Li1AEFG*, Zhen Ye1BD, Hui Ma1CFDOI: 10.12659/MSM.925278
Med Sci Monit 2020; 26:e925278
Table 4 Comparison of alveolar septum thickness and fiber ratio between COPD group and control group.
| Groups | Control (n=20) | COPD | |||
|---|---|---|---|---|---|
| Total (n=40) | Mild (n=8) | Moderate (n=24) | Severe (n=8) | ||
| Thickness(um) | 5.63±1.87 | 6.90±2.11* | 6.19±1.65 | 6.44±1.75 | 9.00±2.39,,** |
| Collagenous fiber (%) | 39.26±10.55 | 47.60±12.62* | 40.88±13.24 | 45.88±9.64 | 59.50±13.52,,** |
| Elastic fibers (%) | 45.31±8.08 | 37.43±12.96* | 40.38±11.70 | 39.63±13.26 | 27.88±9.51,,** |
| Elasticity/collagen | 108.54±37.85 | 82.87±38.85* | 107.55±41.10 | 88.86±35.13 | 48.38±17.97,,** |
| COPD – chronic obstructive pulmonary disease; DLCO – carbon monoxide diffusing capacity; Control group, * ** # ## & && | |||||