18 October 2020 : Clinical Research
Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease
Yongxiang Zhang1ABCDE, Yuechuan Li1AEFG*, Zhen Ye1BD, Hui Ma1CFDOI: 10.12659/MSM.925278
Med Sci Monit 2020; 26:e925278
Table 7 Correlation between alveolar septum thickness and fiber composition ratio and the expression of MMP-2, MMP-9, and TIMP-1.
| r (P) | Linear correlation coefficient | ||
|---|---|---|---|
| Thickness (um) | Collagenous fiber (%) | Elastic fibers (%) | |
| MMP-2 | 0.289 (0.025) | 0.353 (0.006) | −0.271 (0.037) |
| MMP-9 | 0.130 (0.324) | 0.386 (0.002) | −0.268 (0.038) |
| TIMP-1 | 0.417 (0.001) | 0.563 (0.001) | −0.295 (0.022) |
| MMP-2/TIMP-1 | 0.163 (0.215) | −0.120 (0.36) | 0.045 (0.733) |
| MMP-9/TIMP-1 | −0.302 (0.019) | −0.249 (0.055) | 0.098 (0.455) |
| COPD – chronic obstructive pulmonary disease; DLCO – carbon monoxide diffusing capacity; MMP – matrix metalloproteinase; TIMP-1 – tissue inhibitor of metalloproteinase-1. | |||