CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Yiping Zou; Shiye Ruan; Liang Jin; Zhihong Chen; Hongwei Han; Yuanpeng Zhang; Zhixiang Jian; Ye Lin; Ning Shi; Haosheng Jin

doi:10.12659/MSM.925289

31 August 2020 : Database Analysis

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Yiping Zou^12CE, Shiye Ruan^1CD, Liang Jin^1C, Zhihong Chen^1BF, Hongwei Han^1DF, Yuanpeng Zhang^1F, Zhixiang Jian^1G, Ye Lin^1D, Ning Shi^1AE, Haosheng Jin^1AG*

DOI: 10.12659/MSM.925289

Med Sci Monit 2020; 26:e925289

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Table 1 The prognostic values of CpG in CDK1, CCNB1, and CCNB2 genes by MethSurv.

Gene-CpG	HR	Log-rank test P value
CDK1-5′UTR-Island-cg02401235	0.429	<0.001^*
CDK1-5′UTR-Island-cg25793692	0.778	0.15
CDK1-TSS200; 5′UTR; 1stExon-Island-cg04271103	0.866	0.41
CDK1-TSS200; 5′UTR; 1stExon-Island-cg06793798	1.534	0.034^*
CDK1-TSS200; 5′UTR; 1stExon-Island-cg13227273	1.678	0.0038^*
CDK1-TSS200; 5′UTR; 1stExon-Island-cg13954297	0.663	0.024^*
CDK1-TSS200; 5′UTR; 1stExon-Island-cg14922279	0.631	0.0094^*
CDK1-5′UTR; 1stExon; TSS200-Island-cg13554667	0.866	0.41
CDK1-5′UTR; 1stExon; TSS200-Island-cg25228510	2.349	<0.001^*
CDK1-TSS200; TSS1500-Island-cg15172601	0.834	0.3
CDK1-TSS200; TSS1500-Island-cg27457323	0.766	0.18
CDK1-5′UTR; 1stExon; Island-cg18827378	0.674	0.043
CCNB1-TSS1500-N_Shore-cg00290373	1.387	0.062
CCNB1-TSS1500-N_Shore-cg13849825	1.766	0.0016^*
CCNB1-Body-S_Shore-cg01276222	0.571	0.0016^*
CCNB1-Body-Island-cg06452669	1.895	<0.001^*
CCNB1-TSS1500-Island-cg06979550	1.136	0.47
CCNB1-TSS1500-Island-cg20440575	1.907	0.0025^*
CCNB1-TSS200-Island-cg09999250	0.758	0.12
CCNB1-TSS200-Island-cg24088685	1.502	0.032^*
CCNB-1stExon; 5′UTR-Island-cg10556830	0.816	0.25
CCNB-1stExon; 5′UTR-Island-cg23935746	0.826	0.3
CCNB1-3′UTR-Open_Sea-cg13647309	2.688	<0.001^*
CCNB1-Body-S_Shelf-cg17668562	1.418	0.072
CCNB2-TSS1500-N_Shore-cg01738168	1.149	0.43
CCNB2-TSS1500-N_Shore-cg08366813	1.765	0.0018^*
CCNB2-TSS200-N_Shore-cg03950590	1.279	0.16
CCNB2-Body-Island-cg01763821	0.903	0.56
CCNB2-TSS200-Island-cg17236576	1.075	0.72
CCNB2-TSS200-Island-cg17260725	1.184	0.41
CCNB2-Body-S_Shore-cg13581437	1.919	<0.001^*
HR – hazard ratio; ^*

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CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

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