01 October 2020 : Database Analysis
COL3A1, COL6A3, and SERPINH1 Are Related to Glucocorticoid-Induced Osteoporosis Occurrence According to Integrated Bioinformatics Analysis
Liuxun Li1ABCDEF, Meiling Yang2BCDEF, Anmin Jin1ABCDEFG*DOI: 10.12659/MSM.925474
Med Sci Monit 2020; 26:e925474
Table 1 Top 10 genes related to extracellular matrix (ECM) receptor interaction in gene set enrichment analysis (GSEA) details.
| Rank | Gene | Rank in gene list | Rank metric score | Running ES | Core enrichment |
|---|---|---|---|---|---|
| 1 | 11 | 0.466371 | 0.06292749 | Yes | |
| 2 | 22 | 0.402014 | 0.11714857 | Yes | |
| 3 | 28 | 0.38157 | 0.16880953 | Yes | |
| 4 | 38 | 0.360973 | 0.2174943 | Yes | |
| 5 | 45 | 0.338007 | 0.26318827 | Yes | |
| 6 | 59 | 0.307323 | 0.30440277 | Yes | |
| 7 | 78 | 0.288572 | 0.34284827 | Yes | |
| 8 | 98 | 0.26582 | 0.37815624 | Yes | |
| 9 | 140 | 0.221686 | 0.40649727 | Yes | |
| 10 | 156 | 0.211309 | 0.43456927 | Yes | |
| ES – enrichment score; COL3A1 – collagen type III alpha 1 chain; TNN – tenascin N; COL5A1 – collagen type V alpha 1 chain; ITGB6 – integrin subunit beta 6; THBS4 – thrombospondin 4; COL5A2 – collagen type V alpha 2 chain; COL6A3 – collagen type VI alpha 3 chain; THBS2 – thrombospondin 2; COL1A2 – collagen type I alpha 2 chain; SDC2 – syndecan 2. | |||||