06 September 2020 : Animal Research
Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats
Jisheng Wang12ABDE, Xuefeng Gong2ABEF, Fanchao Meng12ABCDEF, Sheng Deng12CDF, Hengheng Dai12BF, Binghao Bao12BE, Junlong Feng12BF, Haisong Li2AG*, Bin Wang2AEDOI: 10.12659/MSM.925579
Med Sci Monit 2020; 26:e925579
Table 2 Top 10 key targets.
| Rank | Name | Score |
|---|---|---|
| 1 | Insulin (INS) | 27 |
| 2 | AKT serine/threonine kinase 1(AKT1) | 26 |
| 2 | Insulin-like growth factor 1 (IGF1) | 26 |
| 2 | Albumin (ALB) | 26 |
| 5 | Vascular endothelial growth factor A (VEGFA) | 24 |
| 5 | Tumor protein P53 (TP53) | 24 |
| 7 | Brain derived neurotrophic factor (BDNF) | 23 |
| 7 | Leptin (LEP) | 23 |
| 7 | Interleukin 6 (IL-6) | 23 |
| 10 | Tumor necrosis factor (TNF) | 22 |
| Key targets were screened using the Cytoscape plug-in cytoHubba. | ||