23 June 2020 : Laboratory Research
A PD-L1 Aptamer Selected by Loss-Gain Cell-SELEX Conjugated with Paclitaxel for Treating Triple-Negative Breast Cancer
Xiaoqiu Wu123BEF, Fangfei Li123AG, Yongshu Li1BF, Yuanyuan Yu13DF, Chao Liang13C, Baoting Zhang4DE, Chuanzong Zhao56B, Aiping Lu12378AG, Ge Zhang123AG*DOI: 10.12659/MSM.925583
Med Sci Monit 2020; 26:e925583
Table 2 IC50 value of RS, XQ-P3, RS-PTX and XQ-P3-PTX after 72 hours incubation with MDA-MB-231 PD-L1 OE cells, MDA-MB-231 PD-L1 KO cells and HCC1937 cells.
| Cell lines | IC50 (nM) | |||
|---|---|---|---|---|
| RS | XQ-P3 | RS-PTX | XQ-P3-PTX | |
| MDA-MB-231 PD-L1 OE | N/A | N/A | 70.92 | 22.07 |
| MDA-MB-231 PD-L1 KO | N/A | N/A | 93.05 | 81.01 |
| HCC-1937 | N/A | N/A | 75.17 | 34.19 |