24 October 2020 : Clinical Research
Risk Factors Affecting Clinical Outcome in Patients with Carbapenem-Resistant K. pneumoniae: A Retrospective Study
Gefei He1DEFG, Juanjuan Huang1DEF, Shiqiong Huang1B, Ji Sun1C, Yulv Zhou2B, Hong Tan3B, Hui Shen4C, Zhuan Li1AG*, Jiyang Liu1AGDOI: 10.12659/MSM.925693
Med Sci Monit 2020; 26:e925693
Table 1 Characteristics of 97 patients with CRKP in the effective and noneffective groups.
| Variable | Total (n=97) | Effective (n=67) | Noneffective (n=30) | p-Value |
|---|---|---|---|---|
| Age | 71.32±16.79 | 71.2±16.37 | 71.57±18.26 | 0.924 |
| Male | 55 (57.00) | 36 (53.73) | 19 (63.33) | 0.383 |
| APCHE2 score | 12.28±5.68 | 11.48±5.31 | 14.73±5.90 | 0.008 |
| Length of hospitalization (days) | 64.91±103.48 | 62.56±99.67 | 70.17±114.76 | 0.741 |
| ICU | 52 (53.61) | 30 (45.78) | 22 (73.33) | 0.09 |
| Surgical | 40 (41.23) | 24 (35.82) | 16 (53.33) | 0.105 |
| History of antimicrobials in the past 90 days | 58 (59.79) | 39 (58.21) | 19 (63.33) | 0.63 |
| Hospital history in the past 90 days | 46 (47.42) | 29 (43.28) | 17 (56.66) | 0.222 |
| Multisite infection | 47 (48.45) | 34 (50.74) | 13 (43.33) | 0.5 |
| Mixed infection | 66 (68.04) | 45 (67.16) | 21 (70.00) | 0.782 |
| Hypertension | 61 (62.88) | 45 (67.16) | 16 (53.33) | 0.193 |
| Diabetes mellitus | 20 (20.62) | 14 (20.89) | 6 (20.00) | 0.92 |
| Hypohepatia | 31 (31.96) | 19 (28.35) | 12 (40.00) | 0.256 |
| Cardiac insufficiency | 52 (53.61) | 37 (55.22) | 15 (50.00) | 0.633 |
| Renal insufficiency | 20 (20.62) | 11 (16.41) | 9 (30.00) | 0.126 |
| Malignancy | 3 (3.09) | 1 (1.49) | 2 (6.67) | 0.174 |
| Hypoproteinemia | 50 (51.55) | 30 (44.77) | 20 (66.67) | 0.046 |
| Mechanical ventilation | 60 (61.85) | 36 (53.73) | 24 (80.00) | 0.014 |
| Arteriovenous catheterization | 50 (51.55) | 29 (43.28) | 21 (70.00) | 0.015 |
| Indwelling gastric tube | 31 (31.96) | 16 (23.88) | 15 (50.00) | 0.011 |
| Indwelling urethral catheter | 68 (70.10) | 42 (62.68) | 26 (86.67) | 0.017 |
| Tracheal intubation | 44 (45.36) | 25 (37.31) | 19 (63.33) | 0.017 |
| Peripherally inserted central venous catheters | 27 (27.83) | 17 (25.37) | 10 (33.33) | 0.419 |
| Indwelling jejunal tube | 9 (9.28) | 4 (5.97) | 5 (16.6) | 0.093 |
| Exposure to carbapenems | 49 (50.52) | 28 (41.79) | 21 (70.00) | 0.01 |
| Exposure to tigecycline | 8 (8.25) | 4 (5.97) | 4 (13.33) | 0.223 |
| Exposure to compound sulfamethoxazole | 4 (4.12) | 3 (4.47) | 1 (3.33) | 0.793 |