24 October 2020 : Clinical Research
Risk Factors Affecting Clinical Outcome in Patients with Carbapenem-Resistant K. pneumoniae: A Retrospective Study
Gefei He1DEFG, Juanjuan Huang1DEF, Shiqiong Huang1B, Ji Sun1C, Yulv Zhou2B, Hong Tan3B, Hui Shen4C, Zhuan Li1AG*, Jiyang Liu1AGDOI: 10.12659/MSM.925693
Med Sci Monit 2020; 26:e925693
Table 4 Univariate analysis of risk factors for poor clinical outcome in patients with CRKP.
| Variable | Effective (n=67) | Noneffective (n=30) | Univariate analysis | |
|---|---|---|---|---|
| OR (95% CI) | P | |||
| Age | 75 (61–84) | 78 (60–83) | 0.710 | |
| Male | 36 | 19 | 0.379 | |
| APCHE2 score | 11 (8–14) | 15 (10–20) | 0.094 | |
| Length of hospitalization (days) | 29 (15–66) | 32 (18–57) | 0.329 | |
| ICU | 30 (45.78) | 22 (73.33) | 3.39 (1.323–8.697) | 0.011 |
| Surgical | 24 (35.82) | 16 (53.33) | 0.108 | |
| History of antimicrobials in the past 90 days | 39 (58.21) | 19 (63.33) | 0.635 | |
| Hospital history in the past 90 days | 29 (43.28) | 17 (56.66) | 0.224 | |
| Multisite infection | 34 (50.74) | 13 (43.33) | 0.5 | |
| Mixed infection | 45 (67.16) | 21 (70.00) | 0.782 | |
| Hypertension | 45 (67.16) | 16 (53.33) | 0.195 | |
| Diabetes mellitus | 14 (20.89) | 6 (20.00) | 0.920 | |
| Hypohepatia | 19 (28.35) | 12 (40.00) | 0.258 | |
| Cardiac insufficiency | 37 (55.22) | 15 (50.00) | 0.634 | |
| Renal insufficiency | 11 (16.41) | 9 (30.00) | 0.131 | |
| Malignancy | 1 (1.49) | 2 (6.67) | 0.213 | |
| Hypoproteinemia | 30 (44.77) | 20 (66.67) | 2.47 (1.004–6.061) | 0.049 |
| Mechanical ventilation | 36 (53.73) | 24 (80.00) | 3.44 (1.248–9.508) | 0.017 |
| Arteriovenous catheterization | 29 (43.28) | 21 (70.00) | 3.06 (1.221–7.659) | 0.017 |
| Indwelling gastric tube | 16 (23.88) | 15 (50.00) | 3.19 (1.283–7.917) | 0.013 |
| Indwelling urethral catheter | 42 (62.68) | 26 (86.67) | 3.87 (1.209–12.383) | 0.023 |
| Tracheal intubation | 25 (37.31) | 19 (63.33) | 2.90 (1.189–7.084) | 0.019 |
| Peripherally inserted central venous catheters | 17 (25.37) | 10 (33.33) | 0.42 | |
| Indwelling jejunal tube | 4 (5.97) | 5 (16.6) | 0.107 | |
| Exposure to carbapenems | 28 (41.79) | 21 (70.00) | 3.25 (1.296–8.151) | 0.012 |
| Exposure to tigecycline | 4 (5.97) | 4 (13.33) | 0.235 | |
| Exposure to compound sulfamethoxazole | 3 (4.47) | 1 (3.33) | 0.794 | |
| CRKP – carbapenem-resistant ; OR – odds ratio; CI – confidence interval. | ||||