Cortical and Subcortical Brain Volume Alterations Following Endurance Running at 38.6 km and 119.2 km in Male Athletes

22 June 2021: Clinical Research

Rabia Hurrem Ozdurak Singin ^1ABCDEFG , Serkan Duz ^2ABCDEFG* , Murat Kiraz ^3ACDE

DOI: 10.12659/MSM.926060

Med Sci Monit 2021; 27:e926060

Table 3 Differences in volume of cortical and subcortical structures before and after 119.8 km race in ultra-trail group.

Volume (cm3)	Prerace (n=14)Mean±SD (Min–Max)	Postrace (n=14)Mean±Sd (Min–Max)	Z	p
Brain total	1259.37±100.41 (1105.79–1421.54)	1274.74±102.25 (1128.13–1426.14)	−2.229	0.026^*
CSF	271.50±46.89 (211.20–368.41)	272.82±51.45 (202.62–394.19)	−0.094	0.925
WM total	550.58±49.54 (493.15–658.62)	551.15±51.24 (467.51–659.81)	−0.534	0.594
GM total	723.59±59.66 (635.6–824.10)	738.12±33.75 (690.60–807.87)	−2.856	0.004^*
Brainstem	25.91±2.22 (23–29.89)	26.07±2.25 (23.07–29.80)	−1.507	0.132
Cerebrum total	1104.69±97.12 (963.51–1262.35)	1110.88±58.38 (1037.74–1189.61)	−2.040	0.041^*
Cerebrum WM	493.78±48.74 (440.07–604.71)	494.97±48.91 (422.67–605)	−0.596	0.551
Cerebrum GM	595.99±352.12 (514.14–981.02)	609.70±55.75 (522.80–706.86)	−2.856	0.004^*
Cerebellum	143.68±13.43 (123.37–168.98)	143.97±13.75 (121.75–167.51)	−0.377	0.706
Thalamus	11.96±1.44 (10.09–15.55)	12.19±1.46 (10.2–15.83)	−2.606	0.009^*
Caudate	7.78±1.10 (6.48–10.45)	7.92±1.19 (6.45–10.9)	−2.041	0.041^*
Putamen	9.09±1.57 (6.62–12.83)	9.29±1.59 (6.65–13.13)	−1.917	0.055
Pallidus	2.62±0.29 (2.27–3.45)	2.71±0.32 (2.47–3.7)	−2.638	0.008^*
Hippocampus	8.75±0.94 (6.95–10.31)	8.85±0.92 (7.09–10.46)	−3.305	0.001^*
Amigdala	1.89±0.25 (1.48–2.29)	1.91±0.25 (1.55–2.34)	−0.420	0.672
Accubens	0.74±0.14 (0.48–0.95)	0.74±0.12 (0.51–0.93)	.000	1.00
^* Significant differences at p CSF – cerebrospinal fluid; GM – gray matter; WM – white matter.