26 September 2020 : Clinical Research
Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19
Cuixing Zhou1BCDE, Yimeng Chen1ABC, Yun Ji2BC, Xiaozhou He1AF*, Dong Xue1AFGDOI: 10.12659/MSM.926178
Med Sci Monit 2020; 26:e926178
Table 2 Clinical laboratory data of participants.
| Patients with COVID-19 n=50 | Healthy controls n=50 | P value | ||
|---|---|---|---|---|
| Severe group n=12 | Mild group n=38 | |||
| WBC,10/L | 4.5±1.6 | 4.8±1.8 | 6.3±2.1 | 0.0006*** |
| RBC, 10/L | 4.6±0.7 | 4.5±0.7 | 4.7±0.6 | 0.718 |
| HB, g/L | 134.2±22.1 | 136.8±16.9 | 143.1±22.2 | 0.203 |
| PLT, 10/L | 204.4±71.9 | 204.7±67.2 | 210.1±62.6 | 0.845 |
| EO, 10/L | 0.04±0.05 | 0.05±0.08 | 0.39±0.28 | <0.0001*** |
| LY, 10/L | 1.4±0.6 | 1.5±0.5 | 2.2±0.8 | <0.01** |
| MO, 10/L | 0.5±0.2 | 0.8±2.0 | 0.6±0.2 | 0.142 |
| Hepcidin,ng/mL | 31.7±8.9 | 25.6±5.8 | 15.7±2.6 | <0.0001*** |
| SF, ng/mL | 207.8±45.2 | 135.6±20.7 | 85.2±18.6 | <0.0001*** |
| Data are presented as mean±SD. WBC – white blood cell count; RBC – red blood cell count; HB – hemoglobin; PLT – platelet count; EO – eosinophil; LY – lymphocyte, MO – monocyte; SF – serum ferritin. P value of each group was measured by one-way analysis of variance (ANOVA). * p ** p *** p | ||||