26 October 2020 : Database Analysis
Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma
Rong-Quan He1A, Zhi-Guang Huang2C, Gao-Qiang Zhai3C, Su-Ning Huang4ACDEF, Yong-Yao Gu2B, Yong-Yao Gu2B, Gang Chen2ACDEF, Jie Ma1B, Ji-Wen Cheng3ACE, Hai-Biao Yan3ADEF, Sheng-hua Li5A*DOI: 10.12659/MSM.926273
Med Sci Monit 2020; 26:e926273
Table 4 Multivariate Cox analysis of OS in BLCA patients of TCGA.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Age | 1.031 (1.014–1.047) | <0.001 | 1.004 (0.975–1.033) | 0.793 |
| Gender | 0.827 (0.588–1.162) | 0.274 | 0.532 (0.297–0.952) | 0.033 |
| AJCC_T stage | 1.651 (1.293–2.108) | <0.001 | 1.271 (0.793–2.037) | 0.319 |
| AJCC_N stage | 1.588 (1.339–1.883) | <0.001 | 1.354 (0.975–1.880) | 0.070 |
| AJCC_M stage | 2.930 (1.258–6.825) | 0.013 | 2.045 (0.637–6.566) | 0.229 |
| Histologic grade | 2.557 (0.631–10.351) | 0.188 | 0.955 (0.121–7.558) | 0.965 |
| SnoRNAs-based risk score | 2.718 (2.131–3.467) | <0.001 | 3.300 (2.203–4.943) | <0.001 |
| Age, AJCC_T stage, AJCC_N stage, snoRNAs-based risk score was coded as continuous variables. Specifically, AJCC_T stage was coded as T1=1, T2=2, T3=3, T4=4. AJCC_N stage was coded as N0=0, N1=1, N2=2, N3=3. The risk factors of gender, AJCC_M stage, subtype and histologic grade are male, metastasis and high Grade. | ||||