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26 October 2020: Database Analysis

Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma

Rong-Quan He 1A , Zhi-Guang Huang 2C , Gao-Qiang Zhai 3C , Su-Ning Huang 4ACDEF , Yong-Yao Gu 2BEF , Gang Chen 2ACDEF , Jie Ma 1B , Ji-Wen Cheng 3ACE , Hai-Biao Yan 3ADEF , Sheng-Hua Li 3A*

DOI: 10.12659/MSM.926273

Med Sci Monit 2020; 26:e926273

Table 4 Multivariate Cox analysis of OS in BLCA patients of TCGA.

VariablesUnivariate analysisMultivariate analysis
Hazard ratio (95% CI)P valueHazard ratio (95% CI)P value
Age1.031 (1.014–1.047)1.004 (0.975–1.033)0.793
Gender0.827 (0.588–1.162)0.2740.532 (0.297–0.952)0.033
AJCC_T stage1.651 (1.293–2.108)1.271 (0.793–2.037)0.319
AJCC_N stage1.588 (1.339–1.883)1.354 (0.975–1.880)0.070
AJCC_M stage2.930 (1.258–6.825)0.0132.045 (0.637–6.566)0.229
Histologic grade2.557 (0.631–10.351)0.1880.955 (0.121–7.558)0.965
SnoRNAs-based risk score2.718 (2.131–3.467)3.300 (2.203–4.943)
Age, AJCC_T stage, AJCC_N stage, snoRNAs-based risk score was coded as continuous variables. Specifically, AJCC_T stage was coded as T1=1, T2=2, T3=3, T4=4. AJCC_N stage was coded as N0=0, N1=1, N2=2, N3=3. The risk factors of gender, AJCC_M stage, subtype and histologic grade are male, metastasis and high Grade.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750