Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

Dawei Ning; Kai Cui; Min Liu; Yang Ou; Zhendan Wang; Benkui Zou; Yangyang Shen; Xinyang Lu; Sheng Li; Pang Li

doi:10.12659/MSM.926565

07 January 2021 : Clinical Research

Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

Dawei Ning^1BCEF, Kai Cui^2BC, Min Liu^2D, Yang Ou^3BCEF, Zhendan Wang^4B, Benkui Zou^5B, Yangyang Shen^6B, Xinyang Lu^7B, Sheng Li^8AG*, Pang Li^9AB

DOI: 10.12659/MSM.926565

Med Sci Monit 2021; 27:e926565

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Table 6 Correlation between circulating tumor cells detected with the CTC-Biopsy system and clinicopathological factors.

Factors	Positive (n=35)	Negative (n=24)	P	Stage I–II (n=8)	P	Stage III–IV (n=27)	P
Age			0.914^*		0.552^*		0.427^*
≥60	17	12		4		13
<60	18	12		4		14
Sex			0.451^*		0.202^*		0.177^*
Male	28	21		8		20
Female	7	3		0		7
Lymphocyte (×10/L)	1.58±0.50	1.67±0.58	0.51^#	1.75±0.36	0.192^#	1.53±0.53	0.411^#
Neutrophils (×10/L)	3.97±1.66	3.94±1.49	0.94^#	4.96±1.97	0.084^#	3.67±1.47	0.327^#
Platelet (×10/L)	266.00±70.65	128.63±26.17	0.64^#	273.38±84.76	0.487^#	263.81±67.61	0.988^#
N/L	2.82±1.53	2.82±1.53	0.72^#	3.01±1.67	^#	2.77±1.51	0.278^#
D-dimer	2.01±4.58	1.32±2.15	0.451^#	0.74±0.49	0.459^#	2.40±5.19	0.297^#
Serum CEA			0.964^*		0.355^*		0.569^*
<3.4	20	14		5		15
≥3.4	13	9		2		11
Other	2	1		1		1
Serum CA199			0.882^*		^**		0.367^*
<39	26	19		5		21
≥39	6	3		1		5
Other	3	2		2		1
Lymph node metastasis			0.498^*		0.737^*		1^**
No	9	9		7		2
Yes	26	15		1		25
Tumor location			0.319^*		0.581^*		0.093^*
Upper third	22	11		3		9
Middle third	8	2		1		7
Lower third	15	11		4		11
Tumor size, cm			0.301^*		0.396^*		0.807^*
<5	15	14		6		9
≥5	15	9		1		14
Other	5	1		1		4
Vascular invasion			0.388^*		0.243^*		0.685^*
No	22	19		7		15
Yes	7	3		0		7
Other	6	2		1		5
Differentiation level			0.196^*		0.753^*		^*
Low	22	10		2		20
Low medium	7	3		2		5
Medium	3	7		2		1
High	1	1		1		1
Other	2	3		1		0
^* χ test; ^** Fisher accurate inspection; ^# Student’s t-test.

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Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

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