07 January 2021>: Clinical Research
Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer
Dawei Ning 1BCEF , Kai Cui 2BC , Min Liu 2D , Yang Ou 3BCEF , Zhendan Wang 4B , Benkui Zou 5B , Yangyang Shen 6B , Xinyang Lu 7B , Sheng Li 8AG* , Pang Li 9AB*DOI: 10.12659/MSM.926565
Med Sci Monit 2021; 27:e926565
Table 7 Correlation between circulating tumor microemboli detected with the CTC-Biopsy system and clinicopathological factors.
Factors | Positive (n=15) | Negative (n=44) | P | Stage I–II (n=2) | P | Stage III–IV (n=13) | P |
---|---|---|---|---|---|---|---|
Age | 0.330* | 1** | 0.427* | ||||
≥60 | 9 | 20 | 1 | 8 | |||
6 | 24 | 1 | 5 | ||||
Sex | 0.445* | 1** | 0.237* | ||||
Male | 11 | 38 | 2 | 9 | |||
Female | 4 | 6 | 0 | 4 | |||
Lymphocyte (×10/L) | 1.50±0.52 | 1.66±0.54 | 0.307# | 1.89±0.04 | 0.950# | 1.43±0.54 | 0.711# |
Neutrophils (×10/L) | 3.70±1.12 | 4.04±1.71 | 0.476# | 3.65±1.13 | 0.635# | 3.71±1.17 | 0.716# |
Platelet (×10/L) | 281.87±60.93 | 254.82±89.42 | 0.282# | 345.50±95.46 | 0.109# | 272.08±52.85 | 0.671# |
N/L | 2.88±1.55 | 2.72±1.57 | 0.727# | 1.94±0.64 | 0.654# | 3.03±1.61 | 0.864# |
D-dimer | 0.87±1.15 | 2.04±4.33 | 0.306# | 0.55±0.07 | 0.703# | 0.92±1.23 | 0.260# |
Serum CEA | 0.903* | ** | 0.324* | ||||
8 | 26 | 0 | 8 | ||||
≥3.4 | 6 | 16 | 1 | 5 | |||
Other | 1 | 2 | 1 | 0 | |||
Serum CA199 | 0.820* | 0.154** | 0.287* | ||||
11 | 34 | 1 | 10 | ||||
≥39 | 3 | 6 | 0 | 3 | |||
Other | 1 | 4 | 1 | 0 | |||
Lymph node metastasis | 0.094* | 1** | 1** | ||||
No | 2 | 17 | 2 | 0 | |||
Yes | 13 | 27 | 0 | 13 | |||
Tumor location | 0.625* | 0.638** | 0.907* | ||||
Upper third | 7 | 16 | 1 | 6 | |||
Middle third | 3 | 7 | 0 | 3 | |||
Lower third | 5 | 21 | 1 | 4 | |||
Tumor size, cm | 0.211* | 0.605** | 0.339* | ||||
24 | 5 | 2 | 3 | ||||
≥5 | 15 | 9 | 0 | 9 | |||
Other | 5 | 1 | 0 | 1 | |||
Vascular invasion | 0.501* | 0.501** | 0.685* | ||||
No | 9 | 32 | 2 | 7 | |||
Yes | 4 | 6 | 0 | 4 | |||
Other | 2 | 6 | 0 | 2 | |||
Differentiation level | 0.277* | 0.346** | ** | ||||
Low | 11 | 21 | 0 | 11 | |||
Low medium | 3 | 7 | 1 | 2 | |||
Medium | 1 | 9 | 1 | 0 | |||
High | 0 | 2 | 0 | 0 | |||
Other | 0 | 5 | 0 | 0 | |||
* χ test; ** Fisher accurate inspection; # Student’s t-test. |