07 January 2021 : Clinical Research
Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer
Dawei Ning1BCEF, Kai Cui2BC, Min Liu2D, Yang Ou3BCEF, Zhendan Wang4B, Benkui Zou5B, Yangyang Shen6B, Xinyang Lu7B, Sheng Li8AG*, Pang Li9ABDOI: 10.12659/MSM.926565
Med Sci Monit 2021; 27:e926565
Table 8 Univariate and multivariate analysis of CellSearch-derived and other factors affecting progression-free survival in patients with gastric cancer.
| Independent factors | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P |
|---|---|---|---|---|---|---|
| CTC (CellSearch) (Yes/No) | 2.556 | 1.278–5.109 | 0.512 | 0.157–1.667 | 0.266 | |
| CTC (≤1/>1) | 5.824 | 2.452–13.833 | 5.367 | 0.427–67.416 | 0.193 | |
| CTC (≤2/>2) | 6.292 | 2.566–15.431 | 8.630 | 0.421–177.118 | 0.162 | |
| CTC (≤3/>3) | 5.358 | 2.136–13.443 | 0.023 | 0.001–0.395 | ||
| CTC (≤4/>4) | 4.859 | 1.775–13.300 | 1.618 | 0.293–8.947 | 0.581 | |
| Age (≤60/>60) | 1.527 | 0.790–2.951 | 0.208 | |||
| Sex (Male/Female) | 1.449 | 0.634–3.314 | 0.380 | |||
| KPS (70–80/90–100) | 0.685 | 0.367–1.279 | 0.235 | |||
| Platelet count | 1.001 | 0.997–1.005 | 0.724 | |||
| N/L | 1.116 | 0.905–1.377 | 0.305 | |||
| CEA (<3.4/≥3.4) | 1.437 | 0.878–2.352 | 0.149 | |||
| CA199 (<39/≥39) | 1.036 | 0.160–0.818 | 0.886 | |||
| Pathological stage (I–II/III–IV) | 14.377 | 3.424–60.372 | 15.475 | 2.426–98.725 | ||
| Distant metastasis (Yes/No) | 11.478 | 4.451–29.595 | 10.310 | 2.796–38.019 | ||
| Lymph node metastasis (Yes/No) | 5.177 | 1.820–14.727 | 0.603 | 0.152–2.383 | 0.470 | |
| Tumor size (<5 cm/≥5 cm) | 2.580 | 1.637–4.067 | 1.385 | 0.588–3.263 | 0.456 | |
| Vascular invasion(Yes/No) | 1.912 | 1.266–2.889 | 0.917 | 0.420–2.003 | 0.829 |