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11 February 2021: Clinical Research

Risk Factors of Coronavirus Disease 2019-Related Mortality and Optimal Treatment Regimens: A Retrospective Study

Yuehong Wang 1BC* , Shuang Yao 2CDEF* , Xiaoling Liu 3BDEF* , Yinghao Cao 4ABCEF , Yaling Wang 5BF* , Mao Xie 6AEF*

DOI: 10.12659/MSM.926751

Med Sci Monit 2021; 27:e926751

Table 6 The factors associated with survival of COVID-19 patients by univariate and multivariate cox regression analysis.

Univariate analysisMultivariate analysis
HR(95% CI)PHR(95% CI)P
Disease severity
 Extremely severe13.3951.773–101.1750.01240.80.551–3023.1500.091
 Kidney injury5.2331.823–15.0160.0024.3800.052–366.3800.513
 Acute heart injury4.5331.600–12.8400.0040.2010.004–11.3850.436
 Secondary bacterial pneumonia2.3200.901–5.9760.081
 Antiviral therap0.2210.084–0.5770.0026.7530.449–101.6450.167
 Arbidol hydrochloride0.2970.040–2.2270.238
 Anti-HIV drugs0.992
 Other treatment0.2640.104–0.6740.0050.0530.003–0.8900.041
 Anti-infection therapy5.4421.227–24.1420.0260.8420.037–19.3830.914
 Gammaglobulin therapy0.1730.040–0.7480.0191.7360.202–14.8940.615
HR – hazard ratio; CI – confidence interval; BMI – body mass index; WBC – white blood cell; NEU – neutrophil; PT – prothrombin; APTT – activated partial thromboplastin time; AST – glutamic oxaloacetylase; TBIL – total bilirubin; DBIL – direct bilirubin; CRE – creatinine; BUN – urea nitrogen; H-CRP – hypersensitive C-reactive protein; ARDS – acute respiratory distress syndrome; CK – creatine kinase; CKMB – creatine kinase isomer-MB.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750