01 December 2020>: Lab/In Vitro Research
Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms
Yaming Guo 1EF* , Shuwei Wan 1EF* , Mingli Han 2C , Yubo Zhao 1B , Chuang Li 1B , Gaopo Cai 1C , Shuai Zhang 1D , Zhi Sun 3D , Xinhua Hu 4F , Hui Cao 1AG** , Zhen Li 1A*DOI: 10.12659/MSM.926766
Med Sci Monit 2020; 26:e926766
Table 1 Clinical and demographic characteristics of patients with abdominal aortic aneurysms and controls.
Characteristics | AAA (n=39) | Control (n=30) | P value |
---|---|---|---|
Age | 72.26±6.773 | 71.40±5.31 | 0.425 |
Female gender, n (%) | 5 (12.8) | 9 (30.0) | 0.073 |
Body mass index, kg/m | 23.96±2.81 | 23.83±3.31 | 0.441 |
Aortic diameter(mm) | 48 (32.1–100.0) | 18 (15.4–23.6) | |
Hypertension, n (%) | 15 (38.5) | 11 (36.7) | 0.54 |
Diabetes mellitus, n (%) | 11 (28.2) | 7 (23.3) | 0.431 |
COPD, n (%) | 4 (28.2) | 3 (23.3) | 0.647 |
Antihypertensive drugs | 5 (12) | 7 (23.3) | 0.205 |
Hypoglycemic agents | 5 (12) | 6 (20.0) | 0.315 |
Current smoker, n (%) | 8 (26.7) | 3 (10.0) | 0.199 |
Ex-smokers, n (%) | 4 (10.2) | 5 (16.7) | 0.612 |
Alcohol drinker, n (%) | 5 (12.8) | 4 (13.3) | 0.612 |
Triacylglycerol, mmol/L | 1.08±0.77 | 1.06±0.68 | 0.798 |
Total cholesterol, mmol/L | 4.49±1.14 | 4.58±1.23 | 0.927 |
HDL-c, mmol/L | 1.81±0.56 | 1.70±0.44 | 0.422 |
LDL-c, mmol/L | 2.28±0.89 | 2.35±0.87 | 0.881 |
Statins, n (%) | 6 (15.4) | 4 (13.3) | 0.546 |
Aspirin, n (%) | 6 (15.4) | 4 (13.3) | 0.546 |
Fibrates, n (%) | 2 (5.1) | 1 (3.3) | 0.599 |
HDL-c – high-density lipoprotein-cholesterol; LDL-c – low-density lipoprotein-cholesterol. |