01 December 2020 : Laboratory Research
Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms
Yaming Guo1EF, Shuwei Wan1EF, Mingli Han1C, Yubo Zhao1B, Chuang Li1B, Gaopo Cai1C, Shuai Zhang1D, Zhi Sun2D, Xinhua Hu3F, Hui Cao1AG*, Zhen Li1ADOI: 10.12659/MSM.926766
Med Sci Monit 2020; 26:e926766
Table 1 Clinical and demographic characteristics of patients with abdominal aortic aneurysms and controls.
| Characteristics | AAA (n=39) | Control (n=30) | P value |
|---|---|---|---|
| Age | 72.26±6.773 | 71.40±5.31 | 0.425 |
| Female gender, n (%) | 5 (12.8) | 9 (30.0) | 0.073 |
| Body mass index, kg/m | 23.96±2.81 | 23.83±3.31 | 0.441 |
| Aortic diameter(mm) | 48 (32.1–100.0) | 18 (15.4–23.6) | <0.01 |
| Hypertension, n (%) | 15 (38.5) | 11 (36.7) | 0.54 |
| Diabetes mellitus, n (%) | 11 (28.2) | 7 (23.3) | 0.431 |
| COPD, n (%) | 4 (28.2) | 3 (23.3) | 0.647 |
| Antihypertensive drugs | 5 (12) | 7 (23.3) | 0.205 |
| Hypoglycemic agents | 5 (12) | 6 (20.0) | 0.315 |
| Current smoker, n (%) | 8 (26.7) | 3 (10.0) | 0.199 |
| Ex-smokers, n (%) | 4 (10.2) | 5 (16.7) | 0.612 |
| Alcohol drinker, n (%) | 5 (12.8) | 4 (13.3) | 0.612 |
| Triacylglycerol, mmol/L | 1.08±0.77 | 1.06±0.68 | 0.798 |
| Total cholesterol, mmol/L | 4.49±1.14 | 4.58±1.23 | 0.927 |
| HDL-c, mmol/L | 1.81±0.56 | 1.70±0.44 | 0.422 |
| LDL-c, mmol/L | 2.28±0.89 | 2.35±0.87 | 0.881 |
| Statins, n (%) | 6 (15.4) | 4 (13.3) | 0.546 |
| Aspirin, n (%) | 6 (15.4) | 4 (13.3) | 0.546 |
| Fibrates, n (%) | 2 (5.1) | 1 (3.3) | 0.599 |
| HDL-c – high-density lipoprotein-cholesterol; LDL-c – low-density lipoprotein-cholesterol. | |||