Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

Yaming Guo; Shuwei Wan; Mingli Han; Yubo Zhao; Chuang Li; Gaopo Cai; Shuai Zhang; Zhi Sun; Xinhua Hu; Hui Cao; Zhen Li

doi:10.12659/MSM.926766

01 December 2020: Lab/In Vitro Research

Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

Yaming Guo ^1EF* , Shuwei Wan ^1EF* , Mingli Han ^2C , Yubo Zhao ^1B , Chuang Li ^1B , Gaopo Cai ^1C , Shuai Zhang ^1D , Zhi Sun ^3D , Xinhua Hu ^4F , Hui Cao ^1AG** , Zhen Li ^1A*

DOI: 10.12659/MSM.926766

Med Sci Monit 2020; 26:e926766

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Table 2 Results of identification of differential metabolites.

Metabolites	Mode	VIP	P	FC	Class	Pathway
2-Oxoglutaric acid	ESI−	1.58		0.33	keto acids	TCA Cycle
Succinic acid	ESI−	1.15		0.59	Dicarboxylic acids	TCA Cycle
Citric acid	ESI−	1.58		0.31	Tricarboxylic acids	TCA Cycle
cis-Aconitic acid	ESI−	1.48		0.01	Tricarboxylic acids	TCA cycle
S1P	ESI+	1.38		0.52	Phosphosphingolipids	Sphingolipid metabolism
Phytosphingosine	ESI+	3.35		0.64	Amines	Sphingolipid metabolism
D-Sphingosine	ESI+	1.81		0.09	Amines	Sphingolipid metabolism
D-carnitine	ESI+	2.50		1.40	Organonitrogen	Lipid metabolism
Hexanoylcarnitine	ESI+	1.07		0.30	Fatty acid esters	Lipid metabolism
L-Octanoylcarnitine	ESI+	2.36		0.35	Fatty acid esters	Lipid metabolism
9-Decenoylcarnitine	ESI+	1.87		0.40	Fatty acid esters	Lipid metabolism
Decanoylcarnitine	ESI+	1.63		0.41	Fatty acid esters	Lipid metabolism
LysoPC (16: 0/0: 0)	ESI+	2.10		0.44	Glycerophosphocholines	Lipid metabolism
PAF	ESI+	1.34		0.60	Glycerophosphoethanolamines	Lipid metabolism
LysoPC (18: 2(9Z,12Z)/0: 0)	ESI+	3.30	0.01	0.85	Glycerophosphocholines	Lipid metabolism
L-Glutamic acid	ESI−	1.3		0.53	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
D-Glutamine	ESI−	1.18		1.45	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
L-Glutamine	ESI+	2.51		1.83	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
Creatine	ESI+	2.23		1.55	Amino acids, peptides, and analogues	Arginine and proline metabolism
L-Proline	ESI+	2.16		1.33	Amino acids, peptides, and analogues	Arginine and proline metabolism
Arginine	ESI+	1.65		3.15	Amino acids, peptides, and analogues	Arginine and proline metabolism
Creatinine	ESI+	2.53		1.66	Amino acids, peptides, and analogues	Arginine and proline metabolism
Pyruvic acid	ESI−	1.08		0.55	Alpha-keto acids and derivatives	Alanine, aspartate and glutamate metabolism
D-Aspartic acid	ESI+	1.45		0.02	Amino acids, peptides, and analogues	Alanine, aspartate and glutamate metabolism
DL-Serine	ESI+	1.27		1.33	Amino acids, peptides, and analogues	Glycine, serine and threonine metabolism
Taurine	ESI−	1.17		0.62	Organosulfonic acids and derivatives	ABC transporters
Betaine	ESI+	3.35		1.22	Amino acids, peptides, and analogues	ABC transporters
L-Phenylalanine	ESI+	5.68		1.37	Amino acids, peptides, and analogues	ABC transporters
L-Isoleucine	ESI+	1.29		1.32	Amino acids, peptides, and analogues	ABC transporters
Choline	ESI+	1.13	0.04	1.23	Organonitrogen compounds	ABC transporters
hypaphorine	ESI−	1.27		0.39	Amino acids, peptides, and analogues	/
L-Threonic acid	ESI−	1.54		0.04	Carbohydrates and carbohydrate conjugates	/
Glutaconic acid	ESI−	1.48		0.05	Dicarboxylic acids and derivatives	/
DL-Tryptophan	ESI−	1.21		2.07	Indolyl carboxylic acids and derivatives	/
[SP]Sphinganine-1-phosphate	ESI−	1.23		0.53	Phosphosphingolipids	/
Monobutyl phthalate	ESI+	1.33		0.31	Benzoic acids and derivatives	/
Piperine	ESI+	1.55		0.10	/	/
N-Phenylacetylglutamine	ESI+	1.48		4.00	Amino acids, peptides, and analogues	/
5-Aminopentanamide	ESI+	3.34		0.18	Amino acids, peptides, and analogues	/
Glu-asp	ESI+	2.63		0.01	Amino acids, peptides, and analogues	/
allylcysteine	ESI+	1.00		0.40	Amino acids, peptides, and analogues	/
Oleamide	ESI+	1.98		0.07	Fatty amides	/
Caffeine	ESI+	1.42		0.14	Purines and purine derivatives	/
Dihydrothymine	ESI+	1.26		2.61	Pyrimidines and pyrimidine derivatives	/
Ubiquinone-1(CoQ1)	ESI+	1.41		0.40	Quinone and hydroquinone lipids	/

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Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

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