Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

Yaming Guo; Shuwei Wan; Mingli Han; Yubo Zhao; Chuang Li; Gaopo Cai; Shuai Zhang; Zhi Sun; Xinhua Hu; Hui Cao; Zhen Li

doi:10.12659/MSM.926766

01 December 2020 : Laboratory Research

Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

Yaming Guo^1EF, Shuwei Wan^1EF, Mingli Han^1C, Yubo Zhao^1B, Chuang Li^1B, Gaopo Cai^1C, Shuai Zhang^1D, Zhi Sun^2D, Xinhua Hu^3F, Hui Cao^1AG*, Zhen Li^1A

DOI: 10.12659/MSM.926766

Med Sci Monit 2020; 26:e926766

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Table 2 Results of identification of differential metabolites.

Metabolites	Mode	VIP	P	FC	Class	Pathway
2-Oxoglutaric acid	ESI−	1.58	<0.001	0.33	keto acids	TCA Cycle
Succinic acid	ESI−	1.15	<0.001	0.59	Dicarboxylic acids	TCA Cycle
Citric acid	ESI−	1.58	<0.001	0.31	Tricarboxylic acids	TCA Cycle
cis-Aconitic acid	ESI−	1.48	<0.001	0.01	Tricarboxylic acids	TCA cycle
S1P	ESI+	1.38	<0.001	0.52	Phosphosphingolipids	Sphingolipid metabolism
Phytosphingosine	ESI+	3.35	<0.001	0.64	Amines	Sphingolipid metabolism
D-Sphingosine	ESI+	1.81	<0.001	0.09	Amines	Sphingolipid metabolism
D-carnitine	ESI+	2.50	<0.001	1.40	Organonitrogen	Lipid metabolism
Hexanoylcarnitine	ESI+	1.07	<0.001	0.30	Fatty acid esters	Lipid metabolism
L-Octanoylcarnitine	ESI+	2.36	<0.001	0.35	Fatty acid esters	Lipid metabolism
9-Decenoylcarnitine	ESI+	1.87	<0.001	0.40	Fatty acid esters	Lipid metabolism
Decanoylcarnitine	ESI+	1.63	<0.001	0.41	Fatty acid esters	Lipid metabolism
LysoPC (16: 0/0: 0)	ESI+	2.10	<0.001	0.44	Glycerophosphocholines	Lipid metabolism
PAF	ESI+	1.34	<0.001	0.60	Glycerophosphoethanolamines	Lipid metabolism
LysoPC (18: 2(9Z,12Z)/0: 0)	ESI+	3.30	0.01	0.85	Glycerophosphocholines	Lipid metabolism
L-Glutamic acid	ESI−	1.3	<0.001	0.53	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
D-Glutamine	ESI−	1.18	<0.001	1.45	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
L-Glutamine	ESI+	2.51	<0.001	1.83	Amino acids, peptides, and analogues	D-Glutamine and D-glutamate metabolism
Creatine	ESI+	2.23	<0.001	1.55	Amino acids, peptides, and analogues	Arginine and proline metabolism
L-Proline	ESI+	2.16	<0.001	1.33	Amino acids, peptides, and analogues	Arginine and proline metabolism
Arginine	ESI+	1.65	<0.001	3.15	Amino acids, peptides, and analogues	Arginine and proline metabolism
Creatinine	ESI+	2.53	<0.001	1.66	Amino acids, peptides, and analogues	Arginine and proline metabolism
Pyruvic acid	ESI−	1.08	<0.001	0.55	Alpha-keto acids and derivatives	Alanine, aspartate and glutamate metabolism
D-Aspartic acid	ESI+	1.45	<0.001	0.02	Amino acids, peptides, and analogues	Alanine, aspartate and glutamate metabolism
DL-Serine	ESI+	1.27	<0.001	1.33	Amino acids, peptides, and analogues	Glycine, serine and threonine metabolism
Taurine	ESI−	1.17	<0.001	0.62	Organosulfonic acids and derivatives	ABC transporters
Betaine	ESI+	3.35	<0.001	1.22	Amino acids, peptides, and analogues	ABC transporters
L-Phenylalanine	ESI+	5.68	<0.001	1.37	Amino acids, peptides, and analogues	ABC transporters
L-Isoleucine	ESI+	1.29	<0.001	1.32	Amino acids, peptides, and analogues	ABC transporters
Choline	ESI+	1.13	0.04	1.23	Organonitrogen compounds	ABC transporters
hypaphorine	ESI−	1.27	<0.001	0.39	Amino acids, peptides, and analogues	/
L-Threonic acid	ESI−	1.54	<0.001	0.04	Carbohydrates and carbohydrate conjugates	/
Glutaconic acid	ESI−	1.48	<0.001	0.05	Dicarboxylic acids and derivatives	/
DL-Tryptophan	ESI−	1.21	<0.001	2.07	Indolyl carboxylic acids and derivatives	/
[SP]Sphinganine-1-phosphate	ESI−	1.23	<0.001	0.53	Phosphosphingolipids	/
Monobutyl phthalate	ESI+	1.33	<0.001	0.31	Benzoic acids and derivatives	/
Piperine	ESI+	1.55	<0.001	0.10	/	/
N-Phenylacetylglutamine	ESI+	1.48	<0.001	4.00	Amino acids, peptides, and analogues	/
5-Aminopentanamide	ESI+	3.34	<0.001	0.18	Amino acids, peptides, and analogues	/
Glu-asp	ESI+	2.63	<0.001	0.01	Amino acids, peptides, and analogues	/
allylcysteine	ESI+	1.00	<0.001	0.40	Amino acids, peptides, and analogues	/
Oleamide	ESI+	1.98	<0.001	0.07	Fatty amides	/
Caffeine	ESI+	1.42	<0.001	0.14	Purines and purine derivatives	/
Dihydrothymine	ESI+	1.26	<0.001	2.61	Pyrimidines and pyrimidine derivatives	/
Ubiquinone-1(CoQ1)	ESI+	1.41	<0.001	0.40	Quinone and hydroquinone lipids	/

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Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms

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