25 October 2020: Database Analysis
Expression and Prognostic Analyses of ITGA3, ITGA5, and ITGA6 in Head and Neck Squamous Cell Carcinoma
Chen Feng 12ABCDEF , Xiaoxue Jin 12ABCD , Yingying Han 12ABCD , Ruixiang Guo 12ABC , Juanjuan Zou 12CDF , Yanzhong Li 12DEFG , Yan Wang 12DEFG*DOI: 10.12659/MSM.926800
Med Sci Monit 2020; 26:e926800
Table 3 The GO function enrichment analysis of ITGA3, ITGA5, and ITGA6 and neighbor genes in head and neck squamous cell carcinoma (HNSC).
| GO | Category | Description | Count | % | Log10(P) | Log10(q) |
|---|---|---|---|---|---|---|
| GO:0031581 | GO Biological Processes | Hemidesmosome assembly | 7 | 58.33 | −21.18 | −16.98 |
| GO:0030198 | GO Biological Processes | Extracellular matrix organization | 14 | 66.67 | −20.44 | −16.54 |
| GO:0007229 | GO Biological Processes | Integrin-mediated signaling pathway | 8 | 66.67 | −16.26 | −13.06 |
| GO:0043589 | GO Biological Processes | Skin morphogenesis | 3 | 25.00 | −7.81 | −5.43 |
| GO:0001525 | GO Biological Processes | Angiogenesis | 7 | 33.33 | −6.34 | −4.11 |
| GO:0000904 | GO Biological Processes | Cell morphogenesis involved in differentiation | 6 | 28.57 | −4.48 | −2.38 |
| GO:0031623 | GO Biological Processes | Receptor internalization | 3 | 14.29 | −3.89 | −1.85 |
| GO:0030100 | GO Biological Processes | Regulation of endocytosis | 3 | 25.00 | −3.48 | −1.46 |
| GO:0043065 | GO Biological Processes | Positive regulation of apoptotic process | 4 | 19.05 | −2.60 | −0.69 |
| GO:0005604 | GO Cellular Components | Basement membrane | 9 | 52.94 | −17.36 | −14.07 |
| GO:0008305 | GO Cellular Components | Integrin complex | 7 | 41.18 | −16.27 | −13.29 |
| GO:0030056 | GO Cellular Components | Hemidesmosome | 4 | 23.53 | −10.93 | −8.90 |
| GO:0005581 | GO Cellular Components | Collagen trimer | 3 | 17.65 | −4.53 | −2.82 |
| GO:0031091 | GO Cellular Components | Platelet alpha granule | 3 | 17.65 | −4.47 | −2.79 |
| GO:0048471 | GO Cellular Components | Perinuclear region of cytoplasm | 5 | 21.74 | −3.28 | −1.73 |
| GO:0005178 | GO molecular functions | Integrin binding | 13 | 65.00 | −24.58 | −20.92 |
| GO:0050840 | GO molecular functions | Extracellular matrix binding | 7 | 58.33 | −15.78 | −12.81 |
| GO:0038132 | GO molecular functions | Neuregulin binding | 3 | 25.00 | −9.03 | −6.54 |
| GO:0005201 | GO molecular functions | Extracellular matrix structural constituent | 6 | 30.00 | −8.48 | −6.02 |
| GO:1901681 | GO molecular functions | Sulfur compound binding | 3 | 15.00 | −2.94 | −0.99 |
| GO:0045296 | GO molecular functions | Cadherin binding | 3 | 15.00 | −2.61 | −0.68 |