27 August 2020 : Clinical Research
Correlation Between QTc Prolongation and Obstructive Sleep Apnea in Patients with Type 2 Diabetes Mellitus
Huan Shi1C, Xiaohong Jiang1A*DOI: 10.12659/MSM.926954
Med Sci Monit 2020; 26:e926954
Table 1 Clinical characteristics of participants stratified according to median corrected QT interval.
| Group 1QTc interval <418 ms (n=176) | Group 2QTc interval ≥418 ms (n=182) | Z/χ2 | P value | |
|---|---|---|---|---|
| Age (years) | 49.00 (40.50, 58.00) | 55.00 (48.00, 65.00) | −5.088 | 0.000 |
| Sex (n, %) | 14.703 | 0.000 | ||
| Male | 140 (79.55) | 111 (60.99) | ||
| Female | 36 (20.45) | 71 (39.01) | ||
| Smoke (n, %) | 1.110 | 0.292 | ||
| Yes | 49 (27.84) | 60 (32.97) | ||
| No | 127 (72.16) | 122 (67.03) | ||
| Hypertension history (n, %) | 12.223 | 0.000 | ||
| Yes | 112 (63.64) | 146 (80.22) | ||
| No | 64 (36.36) | 36 (19.78) | ||
| Fatty liver (n, %) | 8.097 | 0.004 | ||
| Yes | 126 (71.59) | 153 (84.07) | ||
| No | 50 (28.41) | 29 (15.93) | ||
| Height (cm) | 171.00 (165.00, 175.00) | 168.00 (162.00, 173.00) | −3.232 | 0.001 |
| Weight (kg) | 75.00 (66.50, 83.00) | 76.75 (66.00, 86.00) | −1.344 | 0.179 |
| BMI (kg/m) | 25.8 (23.2, 28.3) | 27.0 (25.2, 30.1) | −3.607 | 0.000 |
| Waist circumference (cm) | 92.00 (85.00, 99.00) | 93.00 (86.00, 102.00) | −1.662 | 0.096 |
| Hip circumference (cm) | 98.00 (94.00, 102.50) | 100.00 (94.00, 105.00) | −2.094 | 0.036 |
| Waist-hip ratio | 0.93 (0.90, 0.97) | 0.94 (0.90, 0.98) | −1.244 | 0.213 |
| SBP (mmHg) | 133.50 (124.00, 146.00) | 140.00 (130.00, 154.00) | −3.505 | 0.000 |
| DBP (mmHg) | 84.00 (78.00, 92.00) | 86.00 (80.00, 93.00) | −1.859 | 0.063 |
| Laboratory test | ||||
| ALT (U/L) | 25.00 (18.00, 41.00) | 27.00 (18.00, 41.00) | −0.379 | 0.705 |
| AST (U/L) | 17.00 (12.00, 23.00) | 18.50 (14.00, 27.00) | −2.566 | 0.010 |
| GGT(U/L) | 34.00 (21.00, 55.00) | 37.00 (25.00, 60.00) | −1.698 | 0.089 |
| AKP (U/L) | 79.00 (66.00, 93.00) | 81.00 (67.00, 97.00) | −1.132 | 0.258 |
| LDH (U/L) | 160.50 (132.00, 192.00) | 170.50 (146.00, 202.00) | −2.594 | 0.009 |
| TBL (U/L) | 10.20 (7.65, 13.80) | 9.60 (6.90, 12.10) | −2.214 | 0.027 |
| DBIL (U/L) | 3.20 (2.50, 4.25) | 3.20 (2.30, 4.10) | −0.703 | 0.482 |
| TC (mmol/L) | 4.60 (3.94, 5.19) | 4.67 (4.03, 5.27) | −0.967 | 0.333 |
| TG (mmol/L) | 2.03 (1.46, 3.00) | 2.50 (1.82, 4.10) | −4.386 | 0.000 |
| HDL (mmol/L) | 1.00 (0.86, 1.15) | 0.99 (0.82, 1.14) | −0.914 | 0.361 |
| LDL (mmol/L) | 2.33 (1.94, 2.86) | 2.38 (1.93, 2.82) | −0.054 | 0.957 |
| CR (μmol/L) | 71.00 (59.00, 83.00) | 71.00 (61.00, 81.00) | −0.267 | 0.790 |
| BUN (mmol/L) | 5.19 (4.10, 6.07) | 5.00 (3.98, 6.00) | −1.015 | 0.310 |
| UA (μmol/L) | 288.65 (229.35, 360.70) | 294.15 (235.20, 365.70) | −0.858 | 0.391 |
| FPG (mmol/L) | 9.11 (7.60, 11.40) | 9.71 (7.50, 12.10) | −1.164 | 0.245 |
| HOMA-IR | 1.70 (1.12, 2.29) | 1.90 (1.41, 2.52) | −3.175 | 0.001 |
| HBA1C (%) | 10.00 (8.10, 11.80) | 9.60 (8.00, 11.30) | −1.414 | 0.157 |
| QTc (ms) | 404.00 (396.00, 410.00) | 429.00 (422.00, 440.00) | −16.364 | 0.000 |
| Apnea-hypopnea index (AHI) | 4.30 (2.50, 20.20) | 16.95 (3.50, 40.90) | −4.437 | 0.000 |
| AHI rating (n,%) | 20.837 | 0.000 | ||
| AHI <5 | 90 (51.14) | 56 (30.77) | ||
| 5≤ AHI <15 | 32 (18.18) | 29 (15.93) | ||
| 15≤ AHI <30 | 22 (12.50) | 33 (18.13) | ||
| AHI ≥30 | 32 (18.18) | 64 (35.16) | ||