08 November 2020 : Database Analysis
Identification of the Prognostic Value and Clinical Significance of Interferon Regulatory Factors (IRFs) in Colon Adenocarcinoma
Munire Yuemaier1ABCDEF, Zhiqiang Zhou1AEFG*, Youxu Zhou2ABCDE, Chengwen Wu1CDE, Fei Li1CDEF, Xiaodan Liang1BCEF, Haihan Kang1BCDEF, Dongfang Shen1FG, Fei Gao1EFG, Jinxi Lin2EDOI: 10.12659/MSM.927073
Med Sci Monit 2020; 26:e927073
Table 1 Comparison of gene expression and immune cell landscape.
| Tumor purity | B cells | CD8+T cells | CD4+T cells | Macrophages | Neutrophils | Dendritic cells | |
|---|---|---|---|---|---|---|---|
| r | r | r | r | r | r | r | |
| IRF1 | (−) | (+) | (+) | (+) | (+) | (+++) | (+++) |
| IRF2 | (−) | (++) | (+++) | (++) | (++) | (++) | (+++) |
| IRF3 | (−) | (−) | (−) | (+) | (−) | (−) | (−) |
| IRF4 | (− −) | (++) | (+) | (+++) | (++) | (+++) | (+++) |
| IRF5 | (−) | (−) | (−) | (+) | (++) | (++) | (+) |
| IRF6 | (−) | (+) | (+) | (+) | (+) | (+) | (+) |
| IRF7 | (−) | (−) | (−) | (+) | (+) | (++) | (++) |
| IRF8 | (−) | (+) | (+) | (+) | (+) | (++) | (+) |
| IRF9 | (−) | (+) | (++) | (++) | (++) | (+++) | (+++) |
| Correlation of immune cell landscape of COAD compared with TCGA gene expression of IRFs (TIMER). r – categorized Pearson’s correlation coefficient; (− −): −0.5 to −0.3, weak negative association; (−): −0.3 to 0.1, little association; (+): +0.1 to 0.3, little association; (++): +0.3 to +0.5, weak positive association; (+++): +0.5 to +1.0, strong positive association. | |||||||