08 November 2020: Database Analysis
Identification of the Prognostic Value and Clinical Significance of Interferon Regulatory Factors (IRFs) in Colon Adenocarcinoma
Munire Yuemaier 1ABCDEF* , Zhiqiang Zhou 1AEFG* , Youxu Zhou 2ABCDE , Chengwen Wu 1CDE , Fei Li 1CDEF , Xiaodan Liang 1BCEF , Haihan Kang 1BCDEF , Dongfang Shen 1FG , Fei Gao 1EFG , Jinxi Lin 2E*DOI: 10.12659/MSM.927073
Med Sci Monit 2020; 26:e927073
Table 3 GO function enrichment analysis of IRF family members and neighbor genes in COAD (Metascape).
| GO | Category | Description | Count | % | Log10(P) | Log10(q) |
|---|---|---|---|---|---|---|
| GO: 0060337 | GO biological processes | Type I interferon signaling pathway | 12 | 15.58 | −15.70 | −11.73 |
| GO: 0034341 | GO biological processes | Response to interferon-gamma | 13 | 16.88 | −13.12 | −9.61 |
| GO: 0001817 | GO biological processes | Regulation of cytokine production | 15 | 19.48 | −7.87 | −4.69 |
| GO: 0034612 | GO biological processes | Response to tumor necrosis factor | 9 | 11.69 | −6.14 | −3.09 |
| GO: 0070106 | GO biological processes | Interleukin-27-mediated signaling pathway | 3 | 3.90 | −5.30 | −2.42 |
| GO: 0050856 | GO biological processes | Regulation of T cell receptor signaling pathway | 4 | 5.19 | −5.14 | −2.34 |
| GO: 2001034 | GO biological processes | Positive regulation of double-strand break repair via nonhomologous and joining | 3 | 3.90 | −4.77 | −2.02 |
| GO: 0097191 | GO biological processes | Extrinsic apoptotic signaling pathway | 6 | 7.79 | −4.09 | −1.44 |
| GO: 0003725 | GO Molecular Functions | Double-stranded RNA binding | 4 | 5.19 | −4.01 | −1.37 |
| GO: 0046777 | GO biological processes | Protein autophosphorylation | 6 | 7.79 | −3.97 | −1.36 |
| GO: 1905476 | GO biological processes | Negative regulation of protein localization to membrane | 3 | 3.90 | −3.93 | −1.33 |
| GO: 0035456 | GO biological processes | Response to interferon-beta | 3 | 3.90 | −3.88 | −1.31 |
| GO: 0002683 | GO biological processes | Negative regulation of immune system process | 8 | 10.39 | −3.82 | −1.27 |
| GO: 006302 | GO biological processes | Double-strand break repair | 6 | 7.79 | −3.74 | −1.21 |
| GO: 0030155 | GO biological processes | Regulation of cell adhesion | 9 | 11.69 | −3.35 | −0.90 |
| GO: 0051603 | GO biological processes | Proteolysis involved in cellular protein catabolic process | 9 | 11.69 | −3.29 | −0.87 |
| GO: 0042803 | GO Molecular Functions | Protein homodimerzation activity | 8 | 10.39 | −2.98 | −0.62 |
| GO: 0046579 | GO biological processes | Positive regulation of RAS protein signal transduction | 3 | 3.90 | −2.87 | −0.54 |
| GO: 0002479 | GO biological processes | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 3 | 3.90 | −2.75 | −0.46 |
| GO: 2001252 | GO biological processes | Positive regulation of chromosome organization | 4 | 5.19 | −2.54 | −0.34 |