08 November 2020 : Database Analysis
Identification of the Prognostic Value and Clinical Significance of Interferon Regulatory Factors (IRFs) in Colon Adenocarcinoma
Munire Yuemaier1ABCDEF, Zhiqiang Zhou1AEFG*, Youxu Zhou2ABCDE, Chengwen Wu1CDE, Fei Li1CDEF, Xiaodan Liang1BCEF, Haihan Kang1BCDEF, Dongfang Shen1FG, Fei Gao1EFG, Jinxi Lin2EDOI: 10.12659/MSM.927073
Med Sci Monit 2020; 26:e927073
Table 5 Kinase target networks of the IRF family in COAD.
| IRFs | Enriched kinase target | Description | Leading edge num | P value |
|---|---|---|---|---|
| IRF1 | Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 25 | 0 |
| Kinase_LYN | LYN proto-oncogene,Src family tyrosine Kinase | 26 | 0 | |
| IRF2 | Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 24 | 0 |
| Kinase_SYK | spleen associated tyrosine Kinase | 18 | 0 | |
| IRF3 | Kinase_IKBKB | Inhibitor of nuclear factor Kappa B Kinase subunit bata | 6 | 0 |
| Kinase_PLK3 | polo like Kinase 3 | 5 | 0 | |
| IRF4 | Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 22 | 0 |
| Kinase_LYN | LYN proto-oncogene,Src family tyrosine Kinase | 22 | 0 | |
| IRF5 | Kinase_SYK | Spleen associated tyrosine Kinase | 22 | 0 |
| Kinase_FYN | FYN proto-oncogene,Src family tyrosine Kinase | 31 | 0 | |
| IRF6 | Kinase_ATR | ATR serine/threonine Kinase | 30 | 0 |
| Kinase_STK4 | serine/threonine Kinase | 5 | 0 | |
| IRF7 | Kinase_LYN | LYN proto-oncogene,Src family tyrosine Kinase | 20 | 0 |
| Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 28 | 0 | |
| IRF8 | Kinase_LYN | LYN proto-oncogene,Src family tyrosine Kinase | 27 | 0 |
| Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 21 | 0 | |
| IRF9 | Kinase_LYN | LYN proto-oncogene,Src family tyrosine Kinase | 21 | 0 |
| Kinase_LCK | LCK proto-oncogene,Src family tyrosine Kinase | 25 | 0 |