09 December 2020: Database Analysis
Identification of a 6-Gene Signature Associated with Resistance to Tyrosine Kinase Inhibitors: Prognosis for Clear Cell Renal Cell Carcinoma
Qinke Li ABCE , Wenbo Yang CD , Maoqing Lu DF , Ronggui Zhang AG*DOI: 10.12659/MSM.927078
Med Sci Monit 2020; 26:e927078
Supplementary Table 1 Differentially expressed genes related to tyrosine kinase inhibitor (TKI) resistance.
| Gene | logFC | P. value | Adj. P. value |
|---|---|---|---|
| ACE2 | −2.28 | 5.69E-08 | |
| FOLR1 | −1.89 | 9.51E-09 | |
| PDZK1 | −1.59 | 2.26E-08 | |
| VAV3 | −1.36 | 1.12E-09 | |
| TSPAN12 | −1.35 | 2.04E-08 | |
| SLC17A1 | −1.60 | 1.18E-07 | |
| LOC100506098 | −1.58 | 9.81E-07 | |
| EFHB | −1.50 | 9.24E-07 | |
| KCTD12 | −1.39 | 1.03E-06 | |
| PKHD1 | −1.32 | 1.90E-07 | |
| CYP1B1 | −1.16 | 9.54E-08 | |
| HSPA4L | −1.05 | 4.46E-07 | |
| KDELC1 | −1.01 | 1.62E-07 | |
| DEFB1 | −2.06 | 2.63E-05 | |
| ANO3 | −1.87 | 3.81E-05 | |
| CLDN2 | −1.86 | 4.98E-05 | |
| CALCRL | −1.72 | 8.35E-06 | |
| LOC642757 | −1.60 | 5.48E-05 | |
| C1orf116 | −1.55 | 4.65E-06 | |
| AIF1L | −1.51 | 3.86E-06 | |
| SLC44A4 | −1.47 | 3.22E-05 | |
| FOXJ1 | −1.43 | 1.88E-05 | |
| HIST1H2AE | −1.39 | 1.69E-05 | |
| KCNJ8 | −1.38 | 5.05E-05 | |
| UGT3A1 | −1.33 | 6.49E-05 | |
| HIST1H2BD | −1.18 | 7.94E-06 | |
| HIST1H2AC | −1.15 | 6.98E-05 | |
| ID3 | −1.14 | 6.34E-05 | |
| TINAG | −1.13 | 7.33E-06 | |
| NPDC1 | −1.10 | 1.43E-05 | |
| SPTLC3 | −1.05 | 3.46E-06 | |
| LIN7A | −1.04 | 4.77E-06 | |
| ABCB1 | −1.03 | 4.72E-05 | |
| PEG10 | −1.01 | 7.07E-05 | |
| RP5-1092A3.4 | −1.00 | 7.53E-05 | |
| MMP24 | −1.25 | 7.86E-05 | 0.010 |
| NTN4 | −1.40 | 9.98E-05 | 0.012 |
| ARHGAP6 | −1.06 | 1.02E-04 | 0.012 |
| SLC22A2 | −2.64 | 1.27E-04 | 0.014 |
| HAVCR1 | −1.72 | 1.87E-04 | 0.018 |
| CHST9 | −1.04 | 1.94E-04 | 0.019 |
| THBS1 | −1.29 | 2.05E-04 | 0.019 |
| LOC100422737 | −1.20 | 2.43E-04 | 0.021 |
| ADAMTS15 | −1.21 | 2.52E-04 | 0.022 |
| TSPAN2 | −1.28 | 2.66E-04 | 0.023 |
| SLC29A3 | −1.27 | 2.71E-04 | 0.023 |
| C1orf194 | −1.90 | 3.07E-04 | 0.025 |
| SYT2 | −1.34 | 3.43E-04 | 0.027 |
| PPP1R9A | −1.11 | 3.40E-04 | 0.027 |
| LRRN4 | −1.03 | 3.53E-04 | 0.027 |
| FCAMR | −1.47 | 3.62E-04 | 0.028 |
| LRMP | −1.42 | 4.48E-04 | 0.031 |
| SYT16 | −1.05 | 5.03E-04 | 0.034 |
| LRRC31 | −2.65 | 5.44E-04 | 0.035 |
| ACSM2A | −2.15 | 6.70E-04 | 0.040 |
| SLC17A2 | −1.88 | 6.72E-04 | 0.040 |
| LINC00238 | −1.29 | 8.29E-04 | 0.045 |
| TRIM78P | −1.15 | 8.43E-04 | 0.046 |
| SLITRK4 | −1.19 | 8.63E-04 | 0.046 |
| SLC17A3 | −2.37 | 9.21E-04 | 0.048 |
| RERG | −1.10 | 9.29E-04 | 0.048 |
| EPHA4 | −1.09 | 9.18E-04 | 0.048 |
| LHFPL2 | 1.09 | 5.00E-08 | |
| KIAA1644 | 1.57 | 4.84E-08 | |
| TMEM158 | 2.03 | 1.40E-09 | |
| ETV5 | 1.12 | 1.69E-06 | |
| LTBP1 | 1.14 | 1.44E-06 | |
| PHLDA1 | 1.15 | 4.82E-07 | |
| SCG5 | 2.68 | 4.42E-07 | |
| SLC2A3 | 1.09 | 6.09E-06 | |
| LOC100505592 | 1.11 | 3.25E-05 | |
| LINC00313 | 1.11 | 5.18E-05 | |
| DUSP5 | 1.20 | 3.54E-06 | |
| LDLR | 1.21 | 9.79E-06 | |
| TCN1 | 1.41 | 6.64E-05 | |
| TCHH | 1.44 | 2.98E-05 | |
| MYO1G | 1.54 | 5.21E-05 | |
| MAFF | 1.18 | 1.13E-04 | 0.013 |
| FOSL1 | 1.27 | 1.14E-04 | 0.013 |
| CRYAA | 1.29 | 1.42E-04 | 0.015 |
| CTGF | 1.17 | 1.61E-04 | 0.016 |
| TREM1 | 2.87 | 2.62E-04 | 0.022 |
| PLAT | 2.27 | 4.10E-04 | 0.030 |
| HMGA1 | 1.57 | 5.46E-04 | 0.035 |
| GJB2 | 1.07 | 6.17E-04 | 0.038 |
| C1R | 1.20 | 6.19E-04 | 0.038 |
| ANGPTL4 | 1.60 | 6.21E-04 | 0.038 |
| TF | 1.10 | 6.32E-04 | 0.038 |
| DHRS3 | 1.87 | 7.66E-04 | 0.043 |
| FAM45A | 1.17 | 8.08E-04 | 0.045 |
| IRGM | 1.35 | 9.61E-04 | 0.049 |