04 September 2020 : Clinical Research
Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD)
Yuanzhou He1BCG, Min Xie1DE, Jianping Zhao1CF, Xiansheng Liu1A*DOI: 10.12659/MSM.927212
Med Sci Monit 2020; 26:e927212
Table 4 Clinical features of survivors and non-survivors with severe COVID-19 and COPD.
| Total (n=28) | Survivors (n=6) | Non-survivors (n=22) | P value | |
|---|---|---|---|---|
| Number (%) | Number (%) | Number (%) | ||
| # | 70.5±10.6 | 67.8±8.7 | 72.3±11.4 | 0.379 |
| Male | 24 (85.7) | 4 (66.7) | 20 (90.9) | |
| Female | 4 (14.3) | 2 (33.3) | 2 (9.1) | |
| * | 5 (3–8) | 3.5 (2–5.5) | 5 (3–8) | |
| None | 7 (25.0) | 3 (50.0) | 4 (18.2) | 0.111 |
| LAMA/LABA | 10 (35.7) | 2 (33.3) | 8 (36.4) | 0.891 |
| ICS+LAMA/LABA | 6 (21.4) | 1 (16.7) | 5 (22.7) | 0.748 |
| Oxygen therapy | 3 (10.7) | 0 (0.0) | 3 (13.6) | 0.338 |
| Ventilatory(NIV) support | 2 (7.2) | 0 (0.0) | 2 (9.1) | 0.443 |
| Essential hypertension | 9 (32.1) | 2 (33.3) | 7 (31.8) | 0.944 |
| Diabetes | 5 (17.9) | 2 (33.3) | 3 (13.6) | 0.264 |
| Cardiovascular disease | 10 (35.7) | 3 (50.0) | 7 (31.8) | 0.410 |
| Cerebrovascular disease | 4 (14.3) | 1 (16.7) | 3 (13.6) | 0.851 |
| Chronic kidney disease | 2 (7.1) | 2 (33.3) | 0 (0.0) | |
| Chronic liver disease | 0 (0.0) | 0 (0.0) | 0 (0.0) | – |
| Malignancy | 2 (7.1) | 0 (0.0) | 2 (9.1) | 0.443 |
| Autoimmune disease | 0 (0.0) | 0 (0.0) | 0 (0.0) | – |
| Fever | 24 (85.7) | 4 (66.7) | 20 (90.9) | 0.133 |
| Cough | 28 (100) | 6 (100) | 22 (100) | – |
| Expectoration | 28 (100) | 6 (100) | 22 (100) | – |
| Dyspnea | 28 (100) | 6 (100) | 22 (100) | – |
| Fatigue | 20 (71.4) | 2 (33.3) | 18 (81.8) | |
| Pectoralgia | 1 (3.6) | 0 (0.0) | 1 (4.5) | 0.595 |
| Diarrhea | 7 (25.0) | 2 (33.3) | 5 (22.7) | 0.595 |
| Nausea | 2 (7.1) | 1 (16.7) | 1 (4.5) | 0.307 |
| Vomiting | 2 (7.1) | 0 (0.0) | 2 (9.1) | 0.443 |
| 2.04±1.15 | 1.49±1.12 | 3.39±1.47 | <0.001 | |
| 19 (67.9) | 2 (33.3) | 17 (77.3) | ||
| 28 (100) | 6 (100) | 22 (100) | – | |
| ** | 19 (67.9) | 3 (50.0) | 16 (72.7) | 0.291 |
| *** | 15 (11–19) | 8 (5–13) | ||
| # Mean±SD, years; * data reported as IQR, years; ** invasive mechanical ventilation only; *** data reported as IQR, days. ICU – Intensive Care Unit; SOFA score – Sepsis-related Organ Failure Assessment score. | ||||