Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD)

04 September 2020: Clinical Research

Yuanzhou He ^BCG , Min Xie ^DE , Jianping Zhao ^CF , Xiansheng Liu ^A*

DOI: 10.12659/MSM.927212

Med Sci Monit 2020; 26:e927212

Table 4 Clinical features of survivors and non-survivors with severe COVID-19 and COPD.

	Total (n=28)	Survivors (n=6)	Non-survivors (n=22)	P value
	Number (%)	Number (%)	Number (%)	P value
^#	70.5±10.6	67.8±8.7	72.3±11.4	0.379

Male	24 (85.7)	4 (66.7)	20 (90.9)
Female	4 (14.3)	2 (33.3)	2 (9.1)
^*	5 (3–8)	3.5 (2–5.5)	5 (3–8)

None	7 (25.0)	3 (50.0)	4 (18.2)	0.111
LAMA/LABA	10 (35.7)	2 (33.3)	8 (36.4)	0.891
ICS+LAMA/LABA	6 (21.4)	1 (16.7)	5 (22.7)	0.748
Oxygen therapy	3 (10.7)	0 (0.0)	3 (13.6)	0.338
Ventilatory(NIV) support	2 (7.2)	0 (0.0)	2 (9.1)	0.443

Essential hypertension	9 (32.1)	2 (33.3)	7 (31.8)	0.944
Diabetes	5 (17.9)	2 (33.3)	3 (13.6)	0.264
Cardiovascular disease	10 (35.7)	3 (50.0)	7 (31.8)	0.410
Cerebrovascular disease	4 (14.3)	1 (16.7)	3 (13.6)	0.851
Chronic kidney disease	2 (7.1)	2 (33.3)	0 (0.0)
Chronic liver disease	0 (0.0)	0 (0.0)	0 (0.0)	–
Malignancy	2 (7.1)	0 (0.0)	2 (9.1)	0.443
Autoimmune disease	0 (0.0)	0 (0.0)	0 (0.0)	–

Fever	24 (85.7)	4 (66.7)	20 (90.9)	0.133
Cough	28 (100)	6 (100)	22 (100)	–
Expectoration	28 (100)	6 (100)	22 (100)	–
Dyspnea	28 (100)	6 (100)	22 (100)	–
Fatigue	20 (71.4)	2 (33.3)	18 (81.8)
Pectoralgia	1 (3.6)	0 (0.0)	1 (4.5)	0.595
Diarrhea	7 (25.0)	2 (33.3)	5 (22.7)	0.595
Nausea	2 (7.1)	1 (16.7)	1 (4.5)	0.307
Vomiting	2 (7.1)	0 (0.0)	2 (9.1)	0.443
	2.04±1.15	1.49±1.12	3.39±1.47
	19 (67.9)	2 (33.3)	17 (77.3)
	28 (100)	6 (100)	22 (100)	–
^**	19 (67.9)	3 (50.0)	16 (72.7)	0.291
^***		15 (11–19)	8 (5–13)
^# Mean±SD, years; ^* data reported as IQR, years; ^ invasive mechanical ventilation only; ^* data reported as IQR, days. ICU – Intensive Care Unit; SOFA score – Sepsis-related Organ Failure Assessment score.