04 September 2020>: Clinical Research
Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD)
Yuanzhou He BCG , Min Xie DE , Jianping Zhao CF , Xiansheng Liu A*DOI: 10.12659/MSM.927212
Med Sci Monit 2020; 26:e927212
Table 5 Laboratory findings of survivors and non-survivors with severe COVID-19 and COPD.
Normal range | Survivors (n=6) | Non-survivors (n=22) | P value | |
---|---|---|---|---|
Median (IQR) | Median (IQR) | |||
Leukocyte count, ×10/L | 3.5–9.5 | 6.32 (3.78–8.14) | 9.76 (4.91–14.54) | |
Neutrophil count, ×10/L | 1.8–6.3 | 4.66 (3.02–6.45) | 9.01 (5.27–13.16) | |
Lymphocyte count, ×10/L | 1.1–3.2 | 0.87 (0.49–1.67) | 0.44 (0.31–0.67) | |
Monocyte count, ×10/L | 0.1–0.6 | 0.52 (0.34–0.77) | 0.31 (0.18–0.55) | |
Hemoglobin, g/L | 115–150 | 135 (107–166) | 141 (114–175) | 0.486 |
Platelet count, ×10/L | 125–350 | 173 (120–226) | 182 (134–245) | 0.279 |
ALT, U/L | ≤33 | 21 (14–37) | 24 (18–46) | 0.136 |
AST, U/L | ≤32 | 34 (21–49) | 35 (22–52) | 0.572 |
Albumin, g/L | 35–52 | 33 (21–43) | 25 (19–31) | |
BUN, mmol/L | 3.1–8.8 | 5.4 (3.8–7.5) | 9.2 (6.4–13.6) | |
Cr, μmol/L | 45–104 | 69 (42–93) | 92 (57–121) | |
CK, U/L | ≤170 | 92 (45–129) | 168 (86–296) | |
LDH, U/L | 135–214 | 316 (219–427) | 519 (324–755) | |
NT-BNP, pg/L | 398 (149–998) | 889 (354–2410) | ||
PT, s | 9–13 | 11.9 (9.5–15.8) | 14.2 (10.2–18.5) | 0.061 |
APTT, s | 25–31.3 | 31.8 (23.5–34.8) | 33.4 (24.9–36.1) | 0.215 |
D-dimer, mg/L | 0–0.55 | 2.56 (0.8–6.4) | 7.96 (2.9–14.2) | |
hsCRP, mg/L | 44.3 (29.5–87.4) | 89.1 (35.6–129.2) | ||
ESR, mm/H | 0–20 | 31.2 (17.0–46.0) | 33.5 (18.1–55.6) | 0.538 |
Ferritin, μg/L | 15–150 | 536 (249–1645) | 1569 (579–2598) | |
IL-2R, U/mL | 223–710 | 712 (558–915) | 1024 (796–1357) | |
IL-6, ng/L | 34.2 (8.8–78.5) | 35.9 (9.6–96.7) | 0.479 | |
IL-8 >62 ng/L | 31.5 (13.3–56.5) | 35.2 (15.6–69.8) | 0.172 | |
IL-10 >9.1 ng/L | 12.4 (5.2–14.6) | 14.9 (6.3–15.7) | 0.324 | |
TNF-α >8.1 ng/L | 6.4 (4.9–11.8) | 12.6 (6.7–17.5) | ||
PCT, ng/mL | 0.02–0.05 | 0.14 (0.09–0.28) | 0.47 (0.13–0.58) | |
ALT – alanine aminotransferase; AST – aspartate aminotransferase; UN – urea nitrogen; Cr – creatinine; CK – creatine kinase; LDH – lactic dehydrogenase; PT – prothrombin time; APTT – activated partial thromboplastin time; hsCRP – high sensitive C-reactive protein; ESR – erythrocyte sedimentation rate; IL – interleukin; NT-proBNP – N-terminal pro-brain natriuretic peptide; TNF-α – tumor necrosis factor-α; PCT – procalcitonin. Data expressed as median interquartile range (IQR). values in the 2 groups compared by the χ test, Fisher’s exact test, or the Mann-Whitney U test, as appropriate. |