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04 September 2020: Clinical Research

Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD)

Yuanzhou He BCG , Min Xie DE , Jianping Zhao CF , Xiansheng Liu A*

DOI: 10.12659/MSM.927212

Med Sci Monit 2020; 26:e927212

Table 5 Laboratory findings of survivors and non-survivors with severe COVID-19 and COPD.

Normal rangeSurvivors (n=6)Non-survivors (n=22)P value
Median (IQR)Median (IQR)
 Leukocyte count, ×10/L3.5–9.56.32 (3.78–8.14)9.76 (4.91–14.54)
 Neutrophil count, ×10/L1.8–6.34.66 (3.02–6.45)9.01 (5.27–13.16)
 Lymphocyte count, ×10/L1.1–3.20.87 (0.49–1.67)0.44 (0.31–0.67)
 Monocyte count, ×10/L0.1–0.60.52 (0.34–0.77)0.31 (0.18–0.55)
 Hemoglobin, g/L115–150135 (107–166)141 (114–175)0.486
 Platelet count, ×10/L125–350173 (120–226)182 (134–245)0.279
 ALT, U/L≤3321 (14–37)24 (18–46)0.136
 AST, U/L≤3234 (21–49)35 (22–52)0.572
 Albumin, g/L35–5233 (21–43)25 (19–31)
 BUN, mmol/L3.1–8.85.4 (3.8–7.5)9.2 (6.4–13.6)
 Cr, μmol/L45–10469 (42–93)92 (57–121)
 CK, U/L≤17092 (45–129)168 (86–296)
 LDH, U/L135–214316 (219–427)519 (324–755)
 NT-BNP, pg/L398 (149–998)889 (354–2410)
 PT, s9–1311.9 (9.5–15.8)14.2 (10.2–18.5)0.061
 APTT, s25–31.331.8 (23.5–34.8)33.4 (24.9–36.1)0.215
 D-dimer, mg/L0–0.552.56 (0.8–6.4)7.96 (2.9–14.2)
 hsCRP, mg/L44.3 (29.5–87.4)89.1 (35.6–129.2)
 ESR, mm/H0–2031.2 (17.0–46.0)33.5 (18.1–55.6)0.538
 Ferritin, μg/L15–150536 (249–1645)1569 (579–2598)
 IL-2R, U/mL223–710712 (558–915)1024 (796–1357)
 IL-6, ng/L34.2 (8.8–78.5)35.9 (9.6–96.7)0.479
 IL-8 >62 ng/L31.5 (13.3–56.5)35.2 (15.6–69.8)0.172
 IL-10 >9.1 ng/L12.4 (5.2–14.6)14.9 (6.3–15.7)0.324
 TNF-α >8.1 ng/L6.4 (4.9–11.8)12.6 (6.7–17.5)
 PCT, ng/mL0.02–0.050.14 (0.09–0.28)0.47 (0.13–0.58)
ALT – alanine aminotransferase; AST – aspartate aminotransferase; UN – urea nitrogen; Cr – creatinine; CK – creatine kinase; LDH – lactic dehydrogenase; PT – prothrombin time; APTT – activated partial thromboplastin time; hsCRP – high sensitive C-reactive protein; ESR – erythrocyte sedimentation rate; IL – interleukin; NT-proBNP – N-terminal pro-brain natriuretic peptide; TNF-α – tumor necrosis factor-α; PCT – procalcitonin. Data expressed as median interquartile range (IQR). values in the 2 groups compared by the χ test, Fisher’s exact test, or the Mann-Whitney U test, as appropriate.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750