15 December 2020 : Clinical Research
Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma
Yu Qian1ABCDEF, Jing-Wen Wang1BC, Yu Fang1BCD, Xiao-Dong Yuan1B, Yu-Chen Fan12ADF, Shuai Gao12CDFG, Kai Wang12ADEG*DOI: 10.12659/MSM.927444
Med Sci Monit 2020; 26:e927444
Table 3 CCND2 methylation levels in PBMCs and TNM stage from HCC patients.
| Clinicopathological feature | Variable | Number of cases | Methylation | No methylation | Detection rate (%) |
|---|---|---|---|---|---|
| TNM stage | I | 48 | 16 | 32 | 33.33 |
| II | 24 | 9 | 15 | 37.50 | |
| III | 36 | 23 | 13 | 63.89 | |
| IV | 10 | 7 | 3 | 70.00 | |
| Total | 118 | 55 | 63 | 46.61 | |
| TNM – tumor node metastasis; PBMCs – peripheral blood mononuclear cells. | |||||