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08 December 2020: Database Analysis

Molecular Mechanisms Underlying Intestinal Ischemia/Reperfusion Injury: Bioinformatics Analysis and Validation

Fengshou Chen ABCDEF* , Dan Wang BCDE* , Xiaoqian Li ACD#* , He Wang ACD#*

DOI: 10.12659/MSM.927476

Med Sci Monit 2020; 26:e927476

Table 2 Modules analysis of the protein–protein interaction network.

CategoryModuleScoreNodesEnrichment and pathway descriptionGene
Upregulated DEGsa2020GO: 0007186: G protein-coupled receptor signaling pathwayAckr3, Anxa1, Bdkrb1, Bdkrb2, C5ar1, Ccr1, Ccr5, Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Fpr1, Gal, Gpr31b, Hcar2, Pf4, S1pr1, S1pr3
GO: 0006954: Inflammatory responseAnxa1, Bdkrb1, Bdkrb2, C5ar1, Ccr1, Ccr5, Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Fpr1, Gal, Pf4, S1pr3
mmu04062: Chemokine signaling pathwayCcr1, Ccr5, Cxcl1, Cxcl16, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Pf4
mmu04060: Cytokine–cytokine receptor interactionAckr3, Ccr1, Ccr5, Cxcl1, Cxcl16, Cxcl2, Cxcl5, Cxcr2, Pf4
b99GO: 0002764: Immune response-regulating signaling pathwayCd14, Fcgr2b, Fcgr3, Ptafr
GO: 0050778: Positive regulation of immune responseCd14, Cd44, Fcgr2b, Fcgr3, Ptafr
mmu04145: PhagosomeCd14, Fcgr3
c7.25928GO: 0006954: Inflammatory responseAdam8, Ccl2, Ccl3, Ccl7, Fcer1g, Hmox1, Hp, Icam1, Il10, Il6, Ptgs2, Serpina3n, Slc11a1, Thbs1, Timp1, Tnfrsf1b
GO: 0034097: Response to cytokineCcl2, Ccl3, Ccl7, Fcer1g, Icam1, Il6, Ptgs2, Serpina3c, Serpina3f, Serpina3m, Serpina3n, Serpine1, Slc11a1, Timp1, Tnfrsf1b
mmu04668: TNF signaling pathwayCcl2, Icam1, Il6, Ptgs2, Tnfrsf1b
mmu04060: Cytokine–cytokine receptor interactionCcl2, Ccl3, Ccl7, Il10, Il6, Tnfrsf1b
d5.1438GO: 0006469: Negative regulation of protein kinase activityCblb, Il1b, Socs1, Socs3
GO: 0016567: Protein ubiquitinationCblb, Socs1, Socs3, Spsb1, Znrf1
mmu04120: Ubiquitin mediated proteolysisCblb, Socs1, Socs3
mmu04630: JAK-STAT signaling pathwayCsf3, Socs1, Socs3
Down-regulated DEGse89GO: 0045087: Innate immune responseHerc6, Ifit1, Ifit3, Irf7, Oasl2, Stat2, Zbp1
GO: 0060340: Positive regulation of type I interferon-mediated signaling pathwayIrf7, Zbp1
GO: 0035457: Cellular response to interferon-alphaIfit1, Ifit3
GO: 0035458: Cellular response to interferon-betaIfit1, Ifit3, Stat2
mmu04621: NOD-like receptor signaling pathwayIrf7, Stat2

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750