Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

15 January 2021 : Review article

Jichen Du^1ADE*, Jiangbo Cui^2BC, Jing Yang^1D, Peifu Wang^1B, Lvming Zhang^1D, Bin Luo^1BDF, Bailin Han^1E

DOI: 10.12659/MSM.928108

Med Sci Monit 2021; 27:e928108

Background Ground-based Analogues for Microgravity Cerebral Hemodynamics Current Difficulties Conclusions References

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Table 1 Impact of simulated or actual microgravity on intracranial pressure.

Authors	n	Experimental protocol	Conclusion
Kermorgant et al. []¹⁶	12	3 days of DI	3 days of DI, induced an enlarged ONSD, a surrogate value for estimated ICP
Mader et al. []²¹	1	6 months of spaceflight	After returned to earth, ICP elevated to 22 mmHg and remained high for a period of time
Avan et al. []²²	40	Parabolic flight	Moderate increased ICP during microgravity
Lawley et al. []¹⁹	8	Parabolic flight and 24 h −6° HDBR	HDBR does not progressively increase ICP, but microgravity does prevent the normal lowering of ICP when upright
Arbeille et al. []²³	10	2 h of DI	Due to large individual variability, no substantial changes in ICP have been observed
ICP – intracranial pressure; ONSD – optic nerve sheath diameter; DI – dry immersion; ISS – international space station; HDBR – head-down bed rest.

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