Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

15 January 2021 : Review article

Jichen Du^1ADE*, Jiangbo Cui^2BC, Jing Yang^1D, Peifu Wang^1B, Lvming Zhang^1D, Bin Luo^1BDF, Bailin Han^1E

DOI: 10.12659/MSM.928108

Med Sci Monit 2021; 27:e928108

Background Ground-based Analogues for Microgravity Cerebral Hemodynamics Current Difficulties Conclusions References

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Table 3 Impact of simulated or actual microgravity on cerebrovascular autoregulation.

Authors	n	Experimental protocol	Conclusion
Blaber et al. []³	27	8–16 days of spaceflight	A mismatch of cerebral blood flow with blood pressure has been noticed and it may be the cause of presyncope
Pavy-Le et al. []⁵⁵	8	7-day of −6° HDBR	No major changes found in cerebral autoregulation responses. Nevertheless, the association between cerebral autoregulatory responses and orthostatic intolerance has been noticed
Jeong et al. []⁵¹	21	18-day of −6° HDBR	CA was preserved or improved after HDBR. Furthermore, changes in plasma volume may play an important role in CBF regulation
Iwasaki et al. []³¹	6	1–2 week of spaceflight	CA was preserved, even improved by short-duration spaceflight. This could be attributed to raising responsiveness of cerebral vascular smooth muslce to changes of transmural pressure
Kermorgant et al. []⁵⁷	12	21-day of HDBR	Dynamic CA was improved after 21-day of HDBR
Kermorgant et al. []¹⁶	12	3-day of DI	CA was improved, however, a persistent elevation ICP favours poor CA recovery after 3 days of DI
Kurazumi et al. []⁵³	15	4 bouts 10-min of −10° HDBR/supine combined with placebo/CO	The combination of mild hypercapnia and HDBR attenuated dynamic cerebral autoregulation
CA – cerebrovascular autoregulation; DI – dry immersion; ICP – intracranial pressure; HDBR – head-down bed rest.

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