24 December 2020 : Clinical Research
Comparison of Second- and Third-Generation Parathyroid Hormone Test Results in Patients with Chronic Kidney Disease
Magdalena Wójtowicz1ABCDEF, Wiesław Piechota1CDEF*, Zofia Wańkowicz2DEF, Jerzy Smoszna2DE, Stanisław Niemczyk2DEDOI: 10.12659/MSM.928301
Med Sci Monit 2020; 26:e928301
Table 2 Intact parathyroid hormone, parathyroid hormone 1–84, and other laboratory parameters and age in various subgroups of patients with CKD and in the control group.
| Parameter/test | Study group (n=205) | Control group (n=30) χ̄±SD | ||
|---|---|---|---|---|
| Predialysis period (n=78) χ̄±SD | Hemodialyzed (n=95) χ̄±SD | Peritoneal dialysis (n=32) χ̄±SD | ||
| iPTH (pg/ml) | 155.6±153.2 | 519.4±606.3 | 456.1±400.5 | 38.9±14.6 |
| PTH (1–84) (pg/ml) | 109.5±95.3 | 290.0±324.6 | 245.8±182.0 | 33.8±11.7 |
| Creatinine (mg/dl) | 2.6±1.2 | 7.0±2.5 | 5.9±2.4 | 0.9±0.2 |
| eGFR (ml/min/1.73 m) | 29±12 | 9±5 | 11±6 | 85±16 |
| CKD EPI creatinine-cystatin (ml/min/1.73 m) | 27±12 | 7±2 | 9±4 | 83±14 |
| Urea (mg/dl) | 90±35 | 117±31 | 116±36 | 35±10 |
| Cystatin C (mg/l) | 2.4±0.8 | 5.8±1.0 | 5.2±1.0 | 1.0±0.1 |
| Ca total (mg/dl) | 9.3±1.1 | 8.6±0.7 | 8.9±0.5 | 9.7±0.4 |
| Ca ionized (mmol/l) | 1.17±0.06 | 1.08±0.09 | 1.16±0.07 | 1.16±0.09 |
| Inorganic phosphate (mg/dl) | 3.8±0.8 | 4.8±1.2 | 4.5±1.2 | 3.4±0.5 |
| Mg (mg/dl) | 2.1±0.3 | 2.2±0.3 | 1.9±0.4 | 2.1±0.1 |
| ALP (U/l) | 98±52 | 139±94 | 157±163 | 74±24 |
| BAP (μg/l) | 17.6±8.7 | 31.7±31.6 | 32.2±42.4 | 13.7±5.3 |
| Osteocalcin (ng/ml) | 57.9±52.8 | 277.5±334.2 | 241.3±238.3 | 19.0±7.9 |
| ß-CrossLaps (pg/ml) | 774.6±469.2 | 2088.7±1336.8 | 2525.4±3439.3 | 369.6±162.3 |
| Age (years) | 64±11 | 66±14 | 63±14 | 59±13 |
| * | ** | ** | ** | |
| iPTH (pg/ml) | <0.001 | 0.774 | <0.001 | <0.001 |
| PTH (1–84) (pg/ml) | <0.001 | 0.971 | <0.001 | <0.001 |
| Creatinine (mg/dl) | <0.001 | 0.031 | <0.001 | <0.001 |
| eGFR (ml/min/1.73 m) | <0.001 | 0.058 | <0.001 | <0.001 |
| CKD EPI creatinine-cystatin (ml/min/1.73 m) | <0.001 | 0.010 | <0.001 | <0.001 |
| Urea (mg/dl) | <0.001 | 0.749 | <0.001 | <0.001 |
| Cystatin C (mg/l) | <0.001 | 0.003 | <0.001 | <0.001 |
| Ca total (mg/dl) | <0.001 | 0.004 | <0.001 | <0.001 |
| Ca ionized (mmol/l) | <0.001 | <0.001 | <0.001 | 0.942 |
| Inorganic phosphate (mg/dl) | <0.001 | 0.429 | <0.001 | <0.001 |
| Mg (mg/dl) | <0.001 | <0.001 | 0.380 | <0.001 |
| ALP (U/l) | <0.001 | 0.556 | <0.001 | 0.002 |
| BAP (μg/l) | <0.001 | 0.852 | <0.001 | <0.001 |
| Osteocalcin (ng/ml) | <0.001 | 0.762 | <0.001 | <0.001 |
| β-CrossLaps (pg/ml) | <0.001 | 0.704 | <0.001 | <0.001 |
| Age (years) | 0.0902 | 0.299 | 0.298 | 0.666 |
| * Kruskal-Wallis test; ** Mann-Whitney U test. | ||||