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24 December 2020 : Clinical Research  

Comparison of Second- and Third-Generation Parathyroid Hormone Test Results in Patients with Chronic Kidney Disease

Magdalena Wójtowicz1ABCDEF, Wiesław Piechota1CDEF*, Zofia Wańkowicz2DEF, Jerzy Smoszna2DE, Stanisław Niemczyk2DE

DOI: 10.12659/MSM.928301

Med Sci Monit 2020; 26:e928301

Table 2 Intact parathyroid hormone, parathyroid hormone 1–84, and other laboratory parameters and age in various subgroups of patients with CKD and in the control group.

Parameter/testStudy group (n=205)Control group (n=30) χ̄±SD
Predialysis period (n=78) χ̄±SDHemodialyzed (n=95) χ̄±SDPeritoneal dialysis (n=32) χ̄±SD
iPTH (pg/ml)155.6±153.2519.4±606.3456.1±400.538.9±14.6
PTH (1–84) (pg/ml)109.5±95.3290.0±324.6245.8±182.033.8±11.7
Creatinine (mg/dl)2.6±1.27.0±2.55.9±2.40.9±0.2
eGFR (ml/min/1.73 m)29±129±511±685±16
CKD EPI creatinine-cystatin (ml/min/1.73 m)27±127±29±483±14
Urea (mg/dl)90±35117±31116±3635±10
Cystatin C (mg/l)2.4±0.85.8±1.05.2±1.01.0±0.1
Ca total (mg/dl)9.3±1.18.6±0.78.9±0.59.7±0.4
Ca ionized (mmol/l)1.17±0.061.08±0.091.16±0.071.16±0.09
Inorganic phosphate (mg/dl)3.8±0.84.8±1.24.5±1.23.4±0.5
Mg (mg/dl)2.1±0.32.2±0.31.9±0.42.1±0.1
ALP (U/l)98±52139±94157±16374±24
BAP (μg/l)17.6±8.731.7±31.632.2±42.413.7±5.3
Osteocalcin (ng/ml)57.9±52.8277.5±334.2241.3±238.319.0±7.9
ß-CrossLaps (pg/ml)774.6±469.22088.7±1336.82525.4±3439.3369.6±162.3
Age (years)64±1166±1463±1459±13
* ** ** **
iPTH (pg/ml)0.774
PTH (1–84) (pg/ml)0.971
Creatinine (mg/dl)0.031
eGFR (ml/min/1.73 m)0.058
CKD EPI creatinine-cystatin (ml/min/1.73 m)0.010
Urea (mg/dl)0.749
Cystatin C (mg/l)0.003
Ca total (mg/dl)0.004
Ca ionized (mmol/l)0.942
Inorganic phosphate (mg/dl)0.429
Mg (mg/dl)0.380
ALP (U/l)0.5560.002
BAP (μg/l)0.852
Osteocalcin (ng/ml)0.762
β-CrossLaps (pg/ml)0.704
Age (years)0.09020.2990.2980.666
* Kruskal-Wallis test;
** Mann-Whitney U test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750