Association Between Mitochondrial DNA Copy Number and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Dose-Response Meta-Analysis

20 January 2021: Meta-Analysis

Zhu Zhu ^1ABCDEF , Yixiu Liu ^2B , Didi Wu ^1C , Hongpeng Wang ^2ABCDEF*

DOI: 10.12659/MSM.928327

Med Sci Monit 2021; 27:e928327

Table 1 The baseline characteristics of included studies.

Author	Year	Cancer type	Region	Study Design	Samples	Method for mtDNA
Kim	2004	Head and neck squamous cell carcinoma	America	Case-control	Saliva	qRT-PCR
Jiang	2005	Head and neck squamous cell carcinoma	America	Case-control	Saliva	qRT-PCR
Mondal	2013	Oral squamous cell carcinoma	India	Case-control	Tissues	qRT-PCR
Cheau-Feng Lin	2014	Oral/oropharyngeal/hypopharyngeal/nasopharyngeal/laryngeal/nasal cancer	Taiwan, China	Retrospective cohort	PBL	qRT-PCR
Dang	2014	Laryngeal cancer	Xi’an, China	Cohort	Tissues	qRT-PCR
Ghosh	2014	Nasopharyngeal carcinoma	India	Case-control	PBL	qRT-PCR
He	2014	Oral premalignant lesions	America	Case-control	PBL	qRT-PCR
Wang	2018	Oral cavity/Oropharynx/Larynx/nasal sinuses/parotid/salivary gland	Nanjing, China	Case-control	PBL	qRT-PCR


Kim	14/655	0.0773 (0.0307, 0.2693)^*	0.0257 (0.0134, 0.0584)^*	Cox I	β-actin	4
Jiang	94/656	0.076^**	0.054^**	Cox I	β-actin	6
Jiang	94/656	0.055^**	0.046^**	Cox II	β-actin	6
Mondal	124/140	0.22^*	0.89^*	D-loop	GAPDH	6
Cheau-Feng Lin	75/80	8.22 (4.41, 17.55)^*	4.84^*	tRNA-leu	18s	6
Dang	204/40	11.91±4.35^**	4.72±0.70^**	MT-ND1	β-actin	6
Ghosh	64/100	1.98^*	4.11^*	D-loop	GAPDH	6
He	143/357	1.36±0.74^**	1.11±0.32^**	MT-ND1	HGB	7
Wang	570/597	4.33 (1.38, 29.85)^*	3.5 (1.93, 11.22)^*	MT-ND1	HGB	8
^* Median (first quartile, third quartile) mtDNA copy number level; ^** mean±sd mtDNA copy number level. N – number; NOS – Newcastle-Ottawa Quality Assessment Scale; PBL – peripheral blood lymphocytes; qRT-PCR – real-time quantitative PCR; Cox – cytochrome c oxidase.