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18 February 2021: Database Analysis

Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

Wenjun Jiang 1AC* , Xiaohang Pan 2BF* , Haifan Yan 1EF , Guoping Wang 1AD*

DOI: 10.12659/MSM.928352

Med Sci Monit 2021; 27:e928352

Table 2 Prognostic survival analysis of Hsp70 family genes.

Gene expressionPatients (n=438)No. of events (%)MST (days)Crude HR (95% CI)Crude PAdjusted HR (95% CI)Adjusted P*
0.004
 Low21985.82969Ref.Ref.
 High21969.424120.435 (0.284–0.666)0.514 (0.327–0.808)
0.0370.044
Low21983.62966Ref.Ref.
High21971.724620.645 (0.427–0.974)0.643 (0.419–0.988)
0.0040.046
Low21983.13046Ref.Ref.
High21972.122470.545 (0.362–0.821)0.650 (0.425–0.993)
Low21976.72584Ref.0.776Ref.0.720
High21978.528100.944 (0.635–1.404)1.077 (0.717–1.619)
Low21976.32222Ref.0.103Ref.0.180
High21979.028520.717 (0.481–1.069)1.325 (0.879–1.998)
Low21976.32054Ref.0.134Ref.0.622
High21979.029080.734 (0.490–1.100)0.900 (0.591–1.370)
Low21979.02734Ref.0.656Ref.0.674
High21976.325941.095 (0.736–1.629)1.092 (0.725–1.644)
Low21980.82732Ref.0.067Ref.0.284
High21974.425911.455 (0.975–2.171)1.254 (0.829–1.899)
Low21973.52481Ref.0.050Ref.0.333
High21981.727900.668 (0.446–0.999)0.815 (0.538–1.233)
Low21974.02335Ref.0.017Ref.0.059
High21981.329620.612 (0.409–0.915)0.670 (0.442–1.016)
Low21978.12634Ref.0.863Ref.0.605
High21977.226881.035 (0.697–1.539)1.114 (0.741–1.674)
Low21976.32644Ref.0.935Ref.0.697
High21979.027120.984 (0.661–1.464)0.922 (0.612–1.388)
Low21974.02666Ref.0.189Ref.0.484
High21981.325700.763 (0.510–1.142)0.863 (0.571–1.305)
Low21976.72646Ref.0.388Ref.0.645
High21978.526660.840 (0.565–1.249)0.909 (0.604–1.366)
Low21978.52672Ref.0.836Ref.0.131
High21976.726611.043 (0.701–1.551)0.721 (0.472–1.102)
Low21974.42617Ref.0.244Ref.0.185
High21980.826920.788 (0.528–1.177)0.757 (0.501–1.143)
* Adjusted for TNM stage.
– heat shock protein 70; MST – median survival time; HR – hazard ratio; CI – confidence interval.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750