Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population

07 March 2021: Clinical Research

Jing Liu ^1ABCD , Limin Cai ^1CDEF , Zepeng Zhang ^1BCD , Yanli Ma ^1BCDF , Yongchen Wang ^2ADE*

DOI: 10.12659/MSM.928503

Med Sci Monit 2021; 27:e928503

Table 4 Associations between LEPR SNPs and keloid severity.

SNP	Mild-moderate kleoidn	Severe keloidn	Normal controlsn	P-valuea	P-valueb	OR (95% CI)b	P-valuec	OR (95% CI)c
rs1137101
Dominant AA+GA/GG	60/222	19/51	68/231	0.573	0.435	1.266 (0.700–2.288)	0.292	0.725 (0.399–1.321)
Recessive AA/GA+GG	6/276	5/65	2/297	0.002	0.000	11.423 (2.168–60.176)	0.031	0.283 (0.084–0.955)
Allele G/A	498/66	116/24	528/70	0.180	0.082	0.641 (0.387–1.062)	0.084	1.561 (0.938–2.597)
rs1938496
Dominant CT+CC/TT	106/176	29/41	108/191	0.705	0.408	1.251 (0.736–2.127)	0.554	0.851 (0.500–1.451)
Recessive CC/CT+TT	16/266	8/62	10/289	0.021	0.005	3.729 (1.415–9.830)	0.087	0.466 (0.191–1.138)
Allele C/T	122/442	37/107	118/480	0.200	0.08	1.461 (0.954–2.238)	0.224	0.768 (0.502–1.176)
rs6588147
Dominant GA+AA/GG	65/217	28/42	68/231	0.007	0.003	2.265 (1.307–3.923)	0.004	0.449 (0.259–0.781)
Recessive AA/GA+GG	4/278	6/64	7/292	0.003	0.011	3.911 (1.272–12.028)	0.001	0.153 (0.042–0.560)
Allele G/A	495/69	106/34	523/75	0.001	0.000	0.447 (0.283–0.705)	0.000	2.301 (1.451–3.649)
rs7555955
Dominant GA+GG/AA	90/192	34/36	79/220	0.001	0.000	2.630 (1.541–4.489)	0.009	0.496 (0.292–0.844)
Recessive GG/GA+AA	8/274	8/62	10/289	0.003	0.005	3.729 (1.415–9.830)	0.002	0.226 (0.082–0.626)
Allele G/A	98/466	42/98	89/509	0.000	0.000	2.451 (1.601–3.752)	0.001	0.491 (0.322–0.748)
LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval; n – number. ^a Randomized comparison of mild-moderate keloid, severe keloid and normal controls; ^b Severe keloid vs normal controls; ^c Mild-moderate keloid vs severe keloid.