06 November 2020: Review Articles
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*DOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Introduction to Cerebral Ischemia-Reperfusion
Mitochondrial Dynamics
Mitochondria and Ischemia-Reperfusion (I/R) Injury
Mitochondrial Fusion and Fission
Maintaining the Balance Between Mitochondrial Fusion and Fission
Dysfunctional Mitochondria in Neurons During the I/R Process
Unbalanced Mitochondrial Fusion/Fission Process Leads to Neuronal Apoptosis
Mitochondrial Autophagy Is Involved in Neuronal Death During I/R
Mitochondrial Dynamics and Other Forms of Neuronal Death Induced by I/R
Molecular Mechanisms Underlying Dysfunctional Mitochondrial Dynamics During the I/R Process
Experimental Interventions Targeting Dysfunctional Mitochondrial Dynamics Induced by I/R
Cerebral Ischemia-Reperfusion Drugs Targeting Mitochondrial Dysfunction
Drugs Targeting Mitochondrial ATP Channel
Drugs Targeting Mitochondrial Ca2
Conclusions
References
Table 1 The related proteins of mitochondrial fusion/fission.
| Protein | Related process | Localization | Function | Alteration under I/R condition |
|---|---|---|---|---|
| Mitofusion-1 (Mfn1) []40 | Fusion | OMM | Immediate and continued up-regulation | |
| Mitofusion-2 (Mfn2) []41 | Fusion | OMM | Mild up-regulation after 24 h reperfusion and marked down-regulation after 36 h and 48 h reperfusion | |
| Opa1 []42 | Fusion | IMM | Up-regulation (controversial) | |
| Drp1 []43 | Fission | OMMCytosolic | Up-regulation | |
| Fis1 []44 | Fission | OMM | – | |
| Mff []45 | Fission | OMMPeroxisomal membranes | – | |
| Mid49/45 (MIEF1/2) []46 | Fission | OMMPeroxisomal membranes | – | |
| OMM – outer mitochondrial membrane; IMM – inner mitochondrial membrane; Opa1 – optic atrophy 1; Drp1 – dynamin-related protein 1; Fis1 – fission protein 1; I/R – ischemia-reperfusion. | ||||