06 November 2020 : Review article
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen1BC*, Songxue Guo2D, Yajuan Tang1E, Chaohui Mou3F, Xinben Hu1C, Fangjie Shao1BD, Wei Yan1A, Qun Wu1AGDOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Table 1 The related proteins of mitochondrial fusion/fission.
| Protein | Related process | Localization | Function | Alteration under I/R condition |
|---|---|---|---|---|
| Mitofusion-1 (Mfn1) []40 | Fusion | OMM | Immediate and continued up-regulation | |
| Mitofusion-2 (Mfn2) []41 | Fusion | OMM | Mild up-regulation after 24 h reperfusion and marked down-regulation after 36 h and 48 h reperfusion | |
| Opa1 []42 | Fusion | IMM | Up-regulation (controversial) | |
| Drp1 []43 | Fission | OMMCytosolic | Up-regulation | |
| Fis1 []44 | Fission | OMM | – | |
| Mff []45 | Fission | OMMPeroxisomal membranes | – | |
| Mid49/45 (MIEF1/2) []46 | Fission | OMMPeroxisomal membranes | – | |
| OMM – outer mitochondrial membrane; IMM – inner mitochondrial membrane; Opa1 – optic atrophy 1; Drp1 – dynamin-related protein 1; Fis1 – fission protein 1; I/R – ischemia-reperfusion. | ||||






