Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

06 November 2020: Review Articles

Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review

Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*

DOI: 10.12659/MSM.928651

Med Sci Monit 2020; 26:e928651

Table 2 Interventions targeting mitochondrial fusion/fission under I/R injury.

InterventionsFunctionMechanism
Drp1 siRNA []94 Inhibiting mitochondrial fissionSuppressing the expression of Drp1
Mdivi-1 []95 Inhibiting mitochondrial fissionInhibiting the activity of Drp1
Ginkgolide B []96 Inhibiting mitochondrial fissionReducing Drp1 recruitment and increasing Drp1 phosphorylation at Ser637
P110 []97 Inhibiting mitochondrial fissionInhibiting Drp1 enzyme activity and blocking Drp1/Fis1 interaction
PPARγ agonist []98 Inhibiting mitochondrial fissionSuppressing of Drp1 phosphorylation at Ser616
PINK1 []99 Inhibiting mitochondrial fissionSuppressing of Drp1 phosphorylation at Ser616
AKAP1 []100 Inhibiting mitochondrial fissionIncreasing Drp1 phosphorylation at Ser637
Propofol []101 Inhibiting mitochondrial fissionDecreasing the expression/combination of Drp1 and Fis1
DUSP1 []102 Inhibiting mitochondrial fissionSuppressing Mff phosphorylation
Sirt3 []91 Inhibiting mitochondrial fissionActivating Wnt/β-catenin pathway
Melatonin []103 Promoting mitochondrial fusionActivating the Yap-Hippo pathway
Exercise []104 Promoting mitochondrial fusionElevating level of Opa1
Drp1 – dynamin-related protein 1; Mdivi-1 – Drp1 inhibitor; PINK1 – PTEN-induced kinase 1; AKAP1 – A-kinase anchoring protein 1; DUSP1 – dual specificity protein phosphatase 1; Sirt3 – Sirtuin 3.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750