06 November 2020 : Review article
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen1BC*, Songxue Guo2D, Yajuan Tang1E, Chaohui Mou3F, Xinben Hu1C, Fangjie Shao1BD, Wei Yan1A, Qun Wu1AGDOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Table 2 Interventions targeting mitochondrial fusion/fission under I/R injury.
| Interventions | Function | Mechanism |
|---|---|---|
| Drp1 siRNA []94 | Inhibiting mitochondrial fission | Suppressing the expression of Drp1 |
| Mdivi-1 []95 | Inhibiting mitochondrial fission | Inhibiting the activity of Drp1 |
| Ginkgolide B []96 | Inhibiting mitochondrial fission | Reducing Drp1 recruitment and increasing Drp1 phosphorylation at Ser637 |
| P110 []97 | Inhibiting mitochondrial fission | Inhibiting Drp1 enzyme activity and blocking Drp1/Fis1 interaction |
| PPARγ agonist []98 | Inhibiting mitochondrial fission | Suppressing of Drp1 phosphorylation at Ser616 |
| PINK1 []99 | Inhibiting mitochondrial fission | Suppressing of Drp1 phosphorylation at Ser616 |
| AKAP1 []100 | Inhibiting mitochondrial fission | Increasing Drp1 phosphorylation at Ser637 |
| Propofol []101 | Inhibiting mitochondrial fission | Decreasing the expression/combination of Drp1 and Fis1 |
| DUSP1 []102 | Inhibiting mitochondrial fission | Suppressing Mff phosphorylation |
| Sirt3 []91 | Inhibiting mitochondrial fission | Activating Wnt/β-catenin pathway |
| Melatonin []103 | Promoting mitochondrial fusion | Activating the Yap-Hippo pathway |
| Exercise []104 | Promoting mitochondrial fusion | Elevating level of Opa1 |
| Drp1 – dynamin-related protein 1; Mdivi-1 – Drp1 inhibitor; PINK1 – PTEN-induced kinase 1; AKAP1 – A-kinase anchoring protein 1; DUSP1 – dual specificity protein phosphatase 1; Sirt3 – Sirtuin 3. | ||






