06 November 2020>: Review Articles
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*DOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Introduction to Cerebral Ischemia-Reperfusion
Mitochondrial Dynamics
Mitochondria and Ischemia-Reperfusion (I/R) Injury
Mitochondrial Fusion and Fission
Maintaining the Balance Between Mitochondrial Fusion and Fission
Dysfunctional Mitochondria in Neurons During the I/R Process
Unbalanced Mitochondrial Fusion/Fission Process Leads to Neuronal Apoptosis
Mitochondrial Autophagy Is Involved in Neuronal Death During I/R
Mitochondrial Dynamics and Other Forms of Neuronal Death Induced by I/R
Molecular Mechanisms Underlying Dysfunctional Mitochondrial Dynamics During the I/R Process
Experimental Interventions Targeting Dysfunctional Mitochondrial Dynamics Induced by I/R
Cerebral Ischemia-Reperfusion Drugs Targeting Mitochondrial Dysfunction
Drugs Targeting Mitochondrial ATP Channel
Drugs Targeting Mitochondrial Ca2
Conclusions
References
Table 2 Interventions targeting mitochondrial fusion/fission under I/R injury.
Interventions | Function | Mechanism |
---|---|---|
Drp1 siRNA []94 | Inhibiting mitochondrial fission | Suppressing the expression of Drp1 |
Mdivi-1 []95 | Inhibiting mitochondrial fission | Inhibiting the activity of Drp1 |
Ginkgolide B []96 | Inhibiting mitochondrial fission | Reducing Drp1 recruitment and increasing Drp1 phosphorylation at Ser637 |
P110 []97 | Inhibiting mitochondrial fission | Inhibiting Drp1 enzyme activity and blocking Drp1/Fis1 interaction |
PPARγ agonist []98 | Inhibiting mitochondrial fission | Suppressing of Drp1 phosphorylation at Ser616 |
PINK1 []99 | Inhibiting mitochondrial fission | Suppressing of Drp1 phosphorylation at Ser616 |
AKAP1 []100 | Inhibiting mitochondrial fission | Increasing Drp1 phosphorylation at Ser637 |
Propofol []101 | Inhibiting mitochondrial fission | Decreasing the expression/combination of Drp1 and Fis1 |
DUSP1 []102 | Inhibiting mitochondrial fission | Suppressing Mff phosphorylation |
Sirt3 []91 | Inhibiting mitochondrial fission | Activating Wnt/β-catenin pathway |
Melatonin []103 | Promoting mitochondrial fusion | Activating the Yap-Hippo pathway |
Exercise []104 | Promoting mitochondrial fusion | Elevating level of Opa1 |
Drp1 – dynamin-related protein 1; Mdivi-1 – Drp1 inhibitor; PINK1 – PTEN-induced kinase 1; AKAP1 – A-kinase anchoring protein 1; DUSP1 – dual specificity protein phosphatase 1; Sirt3 – Sirtuin 3. |