Functional Analysis of Estrogen Receptor 1 in Diabetic Wound Healing: A Knockdown Cell-Based and Bioinformatic Study

18 December 2020: Database Analysis

Sha Qi ^ABC , Qiong Han ^BC , Danmou Xing ^D , Long Qian ^CE , Xiang Yu ^E , Dong Ren ^F , Huan Wang ^E , Quan Chen ^ABFG*

DOI: 10.12659/MSM.928788

Med Sci Monit 2020; 26:e928788

Table 1 The upregulated and downregulated differentially expressed genes (DEGs) in biological process.

Term	Function	Count	P-value

GO: 0043547	Positive regulation of GTPase activity	32	3.0E-4
GO: 0072358	Cardiovascular system development	42	4.1E-4
GO: 0072359	Circulatory system development	42	4.1E-4
GO: 0051345	Positive regulation of hydrolase activity	40	8.4E-4
GO: 0007507	Heart development	26	1.1E-3

GO: 0008283	Cell proliferation	70	1.4E-6
GO: 0048608	Reproductive structure development	26	2.6E-6
GO: 0061458	Reproductive system development	26	3.2E-6
GO: 0008285	Negative regulation of cell proliferation	32	1.8E-5
GO: 0010605	Negative regulation of macromolecule metabolic process	77	3.7E-5