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14 February 2021: Database Analysis

Identification of Potential Biomarkers Associated with Prognosis in Gastric Cancer via Bioinformatics Analysis

Dong Li 1ABCDEF* , Yi Yin 2ACEG* , Muqun He 2BDF , Jianfeng Wang 2BDF

DOI: 10.12659/MSM.929104

Med Sci Monit 2021; 27:e929104

Table 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes (DEGs) in gastric cancer.

ExpressionPathway IDNameCount%P-valueGenes
Up- regulatedhsa04512ECM-receptor interaction62.872.58E-07COL1A2, COL1A1, THBS2, COL11A1, THBS4, SPP1
hsa04510Focal adhesion62.871.97E-05COL1A2, COL1A1, THBS2, COL11A1, THBS4, SPP1
hsa04350TGF-beta signaling pathway31.440.011911INHBA, THBS2, THBS4
hsa04670Leukocyte transendothelial migration31.440.021274CLDN7, CLDN4, CLDN1
hsa04514Cell adhesion molecules (CAMs)31.440.026257CLDN7, CLDN4, CLDN1
hsa04530Tight junction31.440.027005CLDN7, CLDN4, CLDN1
Down-regulatedhsa04971Gastric acid secretion90.072.05E-08KCNJ16, KCNJ15, CCKBR, ATP4A, ATP4B, SLC26A7, KCNE2, CA2, SST
hsa00830Retinol metabolism50.048.30E-04ALDH1A1, RDH12, CYP2C9, CYP2C18, UGT2B15
hsa00980Metabolism of xenobiotics by cytochrome P45050.040.001431GSTA1, CYP2C9, AKR7A3, UGT2B15, ALDH3A1
hsa05204Chemical carcinogenesis50.040.001910GSTA1, CYP2C9, CYP2C18, UGT2B15, ALDH3A1
hsa00982Drug metabolism – cytochrome P45040.030.010356GSTA1, CYP2C9, UGT2B15, ALDH3A1
hsa01100Metabolic pathways160.130.010455ETNPPL, PIK3C2G, FUT9, CYP2C9, CYP2C18, ACER2, ALDOB, FBP2, ALDH3A1, RDH12, ALDH1A1, AKR1B10, CKMT2, HDC, UGT2B15, LIPF
hsa04966Collecting duct acid secretion30.020.013808ATP4A, ATP4B, CA2
hsa00051Fructose and mannose metabolism30.020.019104AKR1B10, ALDOB, FBP2

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750