Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess; Shannon Morrison; Brian Haluska; Glenda C. Gobe; Mark A. Jones; Sonia Volante; Bala Venkatesh

doi:10.12659/MSM.929512

18 April 2021 : Animal Research

Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess^1ABCDEFG*, Shannon Morrison^1BCDE, Brian Haluska^2BCD, Glenda C. Gobe^23BCDEG, Mark A. Jones^4ACDE, Sonia Volante^1BE, Bala Venkatesh^2ACDEG

DOI: 10.12659/MSM.929512

Med Sci Monit 2021; 27:e929512

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Table 1 Final assessment of function: LPS model.

Variable	Control	Endotoxin	P-value
MAP (mmHg)	124.29±20.16	81.86±31.67	0.020
Heart rate (bpm)	421.1±47	451.2±46.4	0.20
LVIDs (mm)	0.39±0.12	0.61±0.19	0.13
LVIDd (mm)	0.67±0.11	0.26±0.14	0.70
FS (%)	43.3±9.5	58.8±17.2	0.085
VTI (cm)	9±6	5.27±1.73	0.093
Vpeak (m/s)	4.17±0.74	1.35±1.73	0.17
E (m/s)	0.83±0.24	0.79±0.13	0.65
e′ (m/s)	0.09±0.02	0.06±0.02	0.008
E/e′	8.91±1.51	11.54±3.17	0.19
Analysis of covariance (ANCOVA) performed to compare groups at final time point with adjustment for baseline measurements. LV end-systolic (LVIDs) and end-diastolic (LVIDd) internal dimension; FS – fractional shortening; VTI – velocity time integral; Vpeak – outflow peak velocity; Peak early (E) diastolic transmitral velocity; Peak early (e′) diastolic septal mitral annulus velocity; E/e′ – ratio of E to e′.

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Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

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