Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess; Shannon Morrison; Brian Haluska; Glenda C. Gobe; Mark A. Jones; Sonia Volante; Bala Venkatesh

doi:10.12659/MSM.929512

18 April 2021 : Animal Research

Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess^1ABCDEFG*, Shannon Morrison^1BCDE, Brian Haluska^2BCD, Glenda C. Gobe^23BCDEG, Mark A. Jones^4ACDE, Sonia Volante^1BE, Bala Venkatesh^2ACDEG

DOI: 10.12659/MSM.929512

Med Sci Monit 2021; 27:e929512

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Table 2 Histopathology results for LPS model LV myocardium with HE staining.

Group	Marked hydropic change	Mild hydropic change	Moderate hydropic change	Total
Control (no.)	0	4	3	7
(%)	0.00	57.14	42.86
Endotoxin (no.)	5	0	2	7
(%)	71.43	0.00	28.57
Total	5	4	5	14
Marked hydropic change was observed in five out of seven endotoxic animals, but was not present in any control animals, (P=0.015; Fisher exact). HE – hematoxylin and eosin staining.

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Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

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