Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess; Shannon Morrison; Brian Haluska; Glenda C. Gobe; Mark A. Jones; Sonia Volante; Bala Venkatesh

doi:10.12659/MSM.929512

18 April 2021 : Animal Research

Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess^1ABCDEFG*, Shannon Morrison^1BCDE, Brian Haluska^2BCD, Glenda C. Gobe^23BCDEG, Mark A. Jones^4ACDE, Sonia Volante^1BE, Bala Venkatesh^2ACDEG

DOI: 10.12659/MSM.929512

Med Sci Monit 2021; 27:e929512

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Table 3 Immunohistochemistry for monocyte/macrophage ED1 antibody in LPS model.

Group	No. ED1+ macrophages/monocytes
Group	<5	5–25	25–50	50–75	Total
Control (no.)	4	2	1	0	7
(%)	57.14	28.57	14.29	0.00
Endotoxin (no.)	0	2	3	2	7
(%)	0.00	28.57	42.86	28.57
Total	4	4	4	2	14
Staining for macrophages (ED1) demonstrated increased numbers in the ventricular myocardium of the study group. Five out of 7 endotoxic animals, and no control animals, demonstrated >25 macrophages in at least two out of ten high powered fields (P=0.0095; Cochrane-Armitage test).

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Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

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