Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome

Chang Liu; Xin Yi; Yongnan Lyu; Wei Ren; Yi Zhou; Gaoke Feng; Weiguo Wan; Xue-jun Jiang

doi:10.12659/MSM.929626

24 January 2021 : Clinical Research

Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome

Chang Liu^123ABCD, Xin Yi^123AEG, Yongnan Lyu^123CF, Wei Ren^4CD, Yi Zhou^123BF, Gaoke Feng^123E, Weiguo Wan^123B, Xue-jun Jiang^123AEG*

DOI: 10.12659/MSM.929626

Med Sci Monit 2021; 27:e929626

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Table 3 Correlations of plasma angiopoietinlike protein 5 (ANGPTL5) with laboratory parameters after controlling for the lipid or glucose profiles.

Variables	Ajusted*		Ajusted**		Ajusted***
Variables	r1	P1	r2	P2	r3	P3
BMI	0.583	<0.001	0.282	0.001	0.486	<0.001
Waist circumference	0.567	<0.001	0.240	0.005	0.453	<0.001
WHR	0.545	<0.001	0.269	0.002	0.428	<0.001
SBP	0.255	0.003	0.159	0.068	0.198	0.022
DBP	−0.125	0.146	−0.148	0.091	−0.153	0.077
FPG	0.617	<0.001	–	–	0.525	<0.001
FINS	0.466	<0.001	–	–	0.390	<0.001
HbA1c	0.526	<0.001	–	–	0.443	<0.001
TC	0.324	0.081	−0.004	0.961	–	–
TG	0.310	<0.001	−0.016	0.853	–	–
HDL-C	−0.258	0.002	−0.180	0.039	–	–
LDL-C	0.416	<0.001	0.152	0.081	–	–
hs-CRP	0.259	0.002	0.056	0.520	0.170	0.050
BUN	0.044	0.607	0.036	0.681	0.010	0.907
CREA	−0.064	0.459	−0.018	0.840	−0.113	0.197
URIC	0.209	0.014	0.055	0.531	0.073	0.402
TBIL	−0.012	0.885	0.052	0.553	−0.004	0.965
DBIL	−0.092	0.284	0.080	0.365	−0.010	0.907
IBIL	0.031	0.717	0.024	0.785	−0.004	0.960
AST	0.004	0.962	−0.027	0.763	−0.005	−0.950
ALT	0.058	0.503	0.130	0.138	0.064	0.464
GGT	−0.070	0.416	0.053	0.549	−0.093	0.285
HOMA-IR	0.635	<0.001	–	–	0.556	<0.001
HOMA-β	−0.460	<0.001	–	–	−0.360	<0.001
^* Adjusted for age; ^ adjusted for age+glucose profiles; ^* adjusted for age+lipid profiles. r and P represent correlation coefficient and value after controlling for age. r and P represent correlation coefficient and value after controlling for age and the glucose profiles including fasting plasma glucose (FPG), fasting insulin (FINS), glycated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA of β-cell function (HOMA-β). r and P represent correlation coefficient and value after controlling for age and lipid profiles including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).

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Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome

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