Genome-Wide Profiling of Alternative Splicing Signatures Associated with Prognosis and Immune Microenvironment of Hepatocellular Carcinoma

Zhikun Liu; Jiangwei Ye; Abid Ali Khan; Jun Chen; Lin Zhou; Shusen Zheng; Xiao Xu

doi:10.12659/MSM.930052

18 August 2021 : Database Analysis

Genome-Wide Profiling of Alternative Splicing Signatures Associated with Prognosis and Immune Microenvironment of Hepatocellular Carcinoma

Zhikun Liu^12ABCDEF, Jiangwei Ye^13ABCDE, Abid Ali Khan^12ABCDEF, Jun Chen^12BCDE, Lin Zhou^2BCDE, Shusen Zheng^2ADE, Xiao Xu^12ADG*

DOI: 10.12659/MSM.930052

Med Sci Monit 2021; 27:e930052

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Supplementary Table 3 Univariate Cox analysis of clinical characteristics, the risk score (calculated from the final prognostic signatures) and immune clusters on RFS.

Gene	HR	HRL	HRU	z	p Value
AFP	1.390524915	0.978021476	1.977011329	1.836187514	0.066329929
Age	1.014730874	0.748808106	1.375090279	0.094313179	0.924860381
Stage AJCC	2.462564044	1.778316607	3.41009112	5.425900986	5.77E-08
Histologic grade	1.1159185	0.815391573	1.527209919	0.685114137	0.4932719
Gender	0.898447567	0.650983214	1.239982866	−0.651448262	0.514757165
Vascular invasion	1.871740209	1.31309223	2.668061946	3.465997653	0.000528268
Margin resection status	1.690756072	0.89015302	3.211420994	1.604466361	0.108611294
Risk	2.664870571	1.951169754	3.639629586	6.162677632	7.15E-10
Clusters	1.384500013	0.926179904	2.069619818	1.586099147	0.11271682
Clusters	2.142740551	1.460186979	3.144348727	3.894597278	9.84E-05

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Genome-Wide Profiling of Alternative Splicing Signatures Associated with Prognosis and Immune Microenvironment of Hepatocellular Carcinoma

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