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13 July 2021: Clinical Research

Risk Factors for Fentanyl-Induced Cough Following General Anesthesia in Adults: A Retrospective Study from a Single Center in China

Xiao Zhao ABCDEF* , Hong Wang ABCDEF* , Hui-Juan Wang BCDEF , Yun Wang BCDEF , Yi-An Xing BCD , Shi-Tong Li ABC* , Lian-Hua Chen ABC*

DOI: 10.12659/MSM.930369

Med Sci Monit 2021; 27:e930369

Table 2 The risk factors for the incidence of fentanyl-induced cough by multivariate logistic regression analysis.

Variablesβ valueSDWald chi-squareOR (95% CI)P value
Gender0.0800.2660.0901.083 (0.643–1.822)0.764
Age (years)0.0040.0080.2801.004 (0.989–1.020)0.597
Type of surgery−0.5330.2773.7170.587 (0.341–1.009)0.054
Operative time (min)0.0010.0030.1301.001 (0.996–1.006)0.719
BMI0.0050.0430.0131.005 (0.923–1.094)0.910
Intraoperative blood loss (ml)0.0000.0010.7181.000 (0.999–1.002)0.397
Smoking status0.5160.3122.7281.675 (0.908–3.089)0.099
Alcohol intake0.4200.3831.2021.521 (0.719–3.222)0.273
History of gastroesophageal reflux0.3840.4650.6821.468 (0.590–3.651)0.409
Other digestive tract diseases0.3500.4770.5391.420 (0.557–3.615)0.463
Hypertension0.4380.2922.2511.549 (0.875–2.743)0.134
Diabetes mellitus−0.5840.3632.5820.558 (0.274–1.137)0.108
History of asthma−0.6170.5501.2610.539 (0.184–1.585)0.262
Psychiatric history−0.7920.8340.9010.453 (0.088–2.324)0.343
History of respiratory infection (within 2 months)−0.5080.8540.3540.602 (0.113–3.208)0.552
History of surgery0.6380.4971.6471.893 (0.714–5.019)0.199
Palliative (Dexmedetomidinevs midazolam)0.3850.2502.3631.469 (0.900–2.400)0.124
Sufentanil (ug).
 150.7011.2310.3242.016 (0.181–22.520)0.569
 200.7651.3660.3132.148 (0.148–31.227)0.576
Propofol (mg)−0.0050.0130.1200.995 (0.970–1.022)0.729
Rocuronium bromide−0.0300.0261.3090.971 (0.923–1.021)0.253
Sufentanil−0.0220.0181.5440.978 (0.945–1.013)0.214
BMI – body mass index; CI – confidence interval; OR – odds ratio; SD – standard deviation.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750