Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

16 August 2021: Meta-Analysis

Huangbao Li ^1ACEF , Weiwei Pan ^2AEF , Liu Xu ^1BE , Dong Yin ^3CDE , Shuqun Cheng ^34AEFG* , Fengqing Zhao ^1AEF*

DOI: 10.12659/MSM.930545

Med Sci Monit 2021; 27:e930545

Table 1 Characteristics of included studies.

Study	Year	Country	Total cases	Description of invasion	Type of prognosis
Takahashi et al []²⁰	2020	USA	130	LVI	OS
Panaro et al []¹⁰	2019	France	79	MVI	DFS, OS
Jing et al []¹¹	2019	China	161	MVI	DFS, OS
Tsuchiya et al []¹⁵	2019	Japan	61	MVI	DFS
Groot et al []²¹	2019	USA	957	LVI	DFS
Yamada et al []⁹	2018	Japan	352	MVI	OS
Fang et al []²²	2018	China	496	MVI	OS
Kim et al []²⁴	2018	Korea	70	LVI	OS
Delpero et al []²⁹	2017	France	129	LVI	OS
Epstein et al []¹⁷	2017	USA	2481	LVI	OS
Okumura et al []¹²	2017	Japan	301	MVI	DFS, OS
Liu et al []²³	2016	China	532	MVI	DFS, OS
Wang et al []¹⁴	2013	China	57	MVI	DFS
Crippa et al []⁸	2012	Italy	502	MVI	OS
Chatterjee et al []³⁰	2012	USA	212	LVI	DFS, OS
Hong et al []²⁸	2012	USA	209	MVI	OS
Pawlik et al []⁷	2007	USA	698	MVI	OS
CI – confidence interval; DFS – disease-free survival; HR – Hazard ratio; LVI – lymphovascular invasion; MVI – microvascular invasion; OS – overall survival.