16 August 2021 : Meta-Analysis
Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis
Huangbao Li1ACEF, Weiwei Pan2AEF, Liu Xu1BE, Dong Yin3CDE, Shuqun Cheng34AEFG*, Fengqing Zhao5AEFDOI: 10.12659/MSM.930545
Med Sci Monit 2021; 27:e930545
Table 2 Definition of MVI in PDAC in different studies.
| Study | Description | Origin | Definition methodology | Definition |
|---|---|---|---|---|
| Yamada et al []9 | Microscopic venous invasion | Blood | Elastica-Masson staining | 1 |
| Wang et al []14 | Microvascular invasion | Blood | Immunohistochemical, CD34 as a marker of vascular endothelial cell | 1 |
| Panaro et al []10 | Microvascular invasion | Blood | NA | 1 |
| Naito et al []32 | Lymphovascular invasion and microvessel invasion | Lymph and blood | D2-40 for LVI, Elastica-van Giesson for MVI | 2 |
| Epstein et al []17 | Lymphovascular invasion | Blood or lymph | Hematoxylin and eosin, vascular or lymphatic vessels were not distinguished | 3 |
| Chatterjee et al []30 | Lymphovascular invasion | Blood or lymph | Hematoxylin and eosin, lymphovascular was distinguished by micro-muscular vessels invaded (MVI) or not (LVI) | 4 |
| 1. A cluster of intravascular cancer cells surrounded by an elastic layer; 2. Tumor cell invasion into lymph ducts comprised of D2-40 positive endothelial cells was categorized as LVI. Tumor cell invasion findings in veins with elastic fiber measuring more than half the diameter on Elastica-van Giesson staining or Victoria blue hematoxylin and eosin staining were categorized as MVI; 3. Spreading of cancer cells into microscopic vascular or lymphatic vessels; 4. Tumor invasion into lymphovascular spaces lined by endothelium without muscle layer (LVI) and tumor invasion into micro-muscular vessels (MVI). LVI – lymphovascular invasion; MVI – microvascular invasion. | ||||