Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

16 August 2021: Meta-Analysis

Huangbao Li ^1ACEF , Weiwei Pan ^2AEF , Liu Xu ^1BE , Dong Yin ^3CDE , Shuqun Cheng ^34AEFG* , Fengqing Zhao ^1AEF*

DOI: 10.12659/MSM.930545

Med Sci Monit 2021; 27:e930545

Table 2 Definition of MVI in PDAC in different studies.

Study	Description	Origin	Definition methodology	Definition
Yamada et al []⁹	Microscopic venous invasion	Blood	Elastica-Masson staining	1
Wang et al []¹⁴	Microvascular invasion	Blood	Immunohistochemical, CD34 as a marker of vascular endothelial cell	1
Panaro et al []¹⁰	Microvascular invasion	Blood	NA	1
Naito et al []³²	Lymphovascular invasion and microvessel invasion	Lymph and blood	D2-40 for LVI, Elastica-van Giesson for MVI	2
Epstein et al []¹⁷	Lymphovascular invasion	Blood or lymph	Hematoxylin and eosin, vascular or lymphatic vessels were not distinguished	3
Chatterjee et al []³⁰	Lymphovascular invasion	Blood or lymph	Hematoxylin and eosin, lymphovascular was distinguished by micro-muscular vessels invaded (MVI) or not (LVI)	4
1. A cluster of intravascular cancer cells surrounded by an elastic layer; 2. Tumor cell invasion into lymph ducts comprised of D2-40 positive endothelial cells was categorized as LVI. Tumor cell invasion findings in veins with elastic fiber measuring more than half the diameter on Elastica-van Giesson staining or Victoria blue hematoxylin and eosin staining were categorized as MVI; 3. Spreading of cancer cells into microscopic vascular or lymphatic vessels; 4. Tumor invasion into lymphovascular spaces lined by endothelium without muscle layer (LVI) and tumor invasion into micro-muscular vessels (MVI). LVI – lymphovascular invasion; MVI – microvascular invasion.