Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6

19 August 2021 : Laboratory Research

Ben Wang^1ABEG, Shanjie Wang^2B, Wenke Wang^3BC, Enyu Liu^1BD, Sen Guo^1EF, Chuanzong Zhao^1CF, Jun Niu^1AD, Zongli Zhang^1A*

DOI: 10.12659/MSM.930921

Med Sci Monit 2021; 27:e930921

Background Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 1 Comparison of clinicopathological parameters between non-DM group and DM group.

Clinical factor	No.	Non-DM	DM	P***
No. of patients	203	147	56
Gender				NS
Male	109	79	30
Female	94	68	26
Age				NS
<60	125	90	35
≥60	78	57	21
Location				NS
Colon	162	116	46
Rectum	41	31	10
Differentiation^*				NS
Well	34	23	11
Moderate	137	99	38
Poor	32	25	7
Tumor invasion^*				NS
pT2	29	21	8
pT3	134	98	36
pT4	40	28	12
Lymph node status^*				NS
pN0	106	79	27
pN1	51	37	14
pN2	46	31	15
AJCC stage at diagnosis^*				NS
II	106	79	27
III	97	68	29
Lymphovascular invasion^*				0.012
None	105	84	21
Present	98	63	35
Liver metastasis^**				0.025
None	130	101	29
Present	73	46	27
^* Clinicopathological diagnosis is determined according to TNM system confirmed by at least two pathologists; ^ liver metastasis is diagnosed through imaging examination of CT or MR; ^* value was calculated by Chi-square test. NS – no significance.

Back to the Article