19 August 2021>: Lab/In Vitro Research
Hyperglycemia Promotes Liver Metastasis of Colorectal Cancer via Upregulation of Integrin αvβ6
Ben Wang 1ABEG , Shanjie Wang 2B , Wenke Wang 3BC , Enyu Liu 1BD , Sen Guo 1EF , Chuanzong Zhao 1CF , Jun Niu 1AD* , Zongli Zhang 1A*DOI: 10.12659/MSM.930921
Med Sci Monit 2021; 27:e930921
Table 1 Comparison of clinicopathological parameters between non-DM group and DM group.
Clinical factor | No. | Non-DM | DM | P*** |
---|---|---|---|---|
No. of patients | 203 | 147 | 56 | |
Gender | NS | |||
Male | 109 | 79 | 30 | |
Female | 94 | 68 | 26 | |
Age | NS | |||
125 | 90 | 35 | ||
≥60 | 78 | 57 | 21 | |
Location | NS | |||
Colon | 162 | 116 | 46 | |
Rectum | 41 | 31 | 10 | |
Differentiation* | NS | |||
Well | 34 | 23 | 11 | |
Moderate | 137 | 99 | 38 | |
Poor | 32 | 25 | 7 | |
Tumor invasion* | NS | |||
pT2 | 29 | 21 | 8 | |
pT3 | 134 | 98 | 36 | |
pT4 | 40 | 28 | 12 | |
Lymph node status* | NS | |||
pN0 | 106 | 79 | 27 | |
pN1 | 51 | 37 | 14 | |
pN2 | 46 | 31 | 15 | |
AJCC stage at diagnosis* | NS | |||
II | 106 | 79 | 27 | |
III | 97 | 68 | 29 | |
Lymphovascular invasion* | 0.012 | |||
None | 105 | 84 | 21 | |
Present | 98 | 63 | 35 | |
Liver metastasis** | 0.025 | |||
None | 130 | 101 | 29 | |
Present | 73 | 46 | 27 | |
* Clinicopathological diagnosis is determined according to TNM system confirmed by at least two pathologists; ** liver metastasis is diagnosed through imaging examination of CT or MR; *** value was calculated by Chi-square test. NS – no significance. |