12 August 2021: Review Articles
Recent Advances in Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Promoted by Mechanical Stretch
Xingwang Gu 1ABCF , Fan Zhou 2ABEF* , Junsheng Mu 3ADFG*DOI: 10.12659/MSM.931063
Med Sci Monit 2021; 27:e931063
Table 2 Recent studies focused on the maturation of PSC-CMs promoted by mechanical stretch since 2015.
| Publication year & main author | Cell types | Stimulations | Parameters of mechanical stretch | Impact of stretch on structure | Impact of stretch on function |
|---|---|---|---|---|---|
| 2020Kreutzer | hiPSC-CMs | Mechanical stretch only | – | ||
| 2019Labarge | hiPSC-CMs | – | |||
| 2018Ronaldson-Bouchard | hiPSC-CMs | Electrical stimulation induced mechanical stretch | |||
| 2018Ovchinnikova | hESC-CMs | Mechanical stretch only | |||
| 2018Abilez | hiPSC-CMs; hESC-CMs | Mechanical stretch only | |||
| 2017Zhang | hESC-CMs | Mechanical stretch on hESC-CMs cocultured with Nicole cells | |||
| 2017Shen | hESC-CMs; mESC-CMs | Increased expression of cardiac genes in mESC-CMs, especially under 5% elongation | Proper cardiac electrophysiology, Ca2+ handling and responses to Nifedipine in hESC-CMs under combining stimulation | ||
| 2017Kroll | hiPSC-CMs | No improvements in neither microstructure nor expression of cardiac genes under single mechanical stretch | Increased percentage of the cells expressing the L-type membrane current under single mechanical stretch | ||
| 2016Ruan | hiPSC-CMs | ||||
| 2015Ruan | hESC and hiPSC-derived cardiovascular progenitors (CVP) | Mechanical stretch in 3D microenvironment | |||
| 2015Qi | hESC-CMs | Mechanical stretch only | Realignment of hESC-CMs in the direction transverse to the direction of stretch, with the percentage of realigned cells positively correlated with the degree of elongation | – |