14 August 2021 : Database Analysis
Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes
Yuanlong Hu1ACE, Xiaomeng Cheng1BCEF, Zhanjun Qiu2ADG*, Xianhai Chen2ADFGDOI: 10.12659/MSM.931222
Med Sci Monit 2021; 27:e931222
Table 1 Differences in clinical characteristics among subtypes in the GSE47460-GPL14550 dataset.
| Variable | Subtype* | P-value** | ||
|---|---|---|---|---|
| 1 (N=28) | 2 (N=57) | 3 (N=60) | ||
| Age, y | 66 (61, 71) | 68 (60, 73) | 67 (61, 72) | 0.7 |
| Sex, n (%) | 0.7 | |||
| Female | 12 (43) | 24 (42) | 30 (50) | |
| Male | 16 (57) | 33 (58) | 30 (50) | |
| Smoking status, n (%) | 0.7 | |||
| Current | 2 (7.1) | 5 (8.8) | 4 (6.7) | |
| Ever | 24 (86) | 47 (82) | 54 (90) | |
| Never | 2 (7.1) | 5 (8.8) | 2 (3.3) | |
| Emphysema, % | 7 (3, 26) | 12 (2, 28) | 5 (1, 16) | 0.4 |
| DLCO, %predicted | 46 (35, 68) | 48 (38, 67) | 60 (48, 77) | 0.068 |
| FEV (pre-BD), %predicted | 54 (26, 73) | 58 (28, 66) | 52 (44, 66) | 0.9 |
| FEV (post-BD), %predicted | 58 (33, 70) | 58 (32, 72) | 58 (51, 70) | 0.9 |
| FVC (pre-BD), %predicted | 73 (62, 90) | 75 (64, 86) | 78 (66, 88) | 0.9 |
| FVC (post-BD), %predicted | 81 (74, 93) | 80 (69, 91) | 84 (71, 94) | 0.9 |
| BD – bronchodilator; DLCO – diffusing capacity for carbon monoxide; FEV – forced expiratory volume in the first second of expiration; FVC – forced vital capacity; IQR – interquartile range. * Statistics presented: median (IQR); n (%); ** statistical tests performed: Wilcoxon rank-sum test, Fisher’s exact test, and chi-square test of independence. | ||||